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Table 1 Small intestinal histopathology classifications – a comparison

From: Validation study of villous atrophy and small intestinal inflammation in Swedish biopsy registers

Classification used in this project Normal Inflammation Villous atrophy
Marsh Classification* Type 0 Type 1 Type 2 Type 3a Type 3b Type 3c
Marsh
Description
Pre-infitrative Infiltrative Infiltrative-hyperplastic Flat destructive
Corazza et al [5] - Grade A Grade B1 Grade B2
SnoMed Codes M0010,
M0011
M40000, M41000,
M42000, M43000,
M47000, M47170
M58,
D6218,
M58005
M58,
D6218,
M58006
M58,
D6218,
M58007
KVAST/Alexander classification I
Normal
II
Intraepithelial lymphocytosis (IEL)#
III
Partial VA
IV
Subtotal VA
IV
Total VA
Characteristics       
Villous atrophy - - - + ++ ++
IEL# - + + + + +
Crypt hyperplasia - - + + ++ ++
  1. *We have not included Marsh type 4 in this classification since such lesions are very rare [9] and cannot be identified through SnoMed Codes.
  2. # Increased intraepithelial lymphocyte count (often >30/100 epithelial cells).