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Table 1 Study characteristics

From: A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

First author Number of participants (age range)l Diagnostic criteria Probiotics* Measured outcomes included: Length of treatment
Guyonnet, 2007, France 274
Rome II
Predominant IBS
Activia Danone, Combination containing Bifidobacterium. animalis DN 1730101(1.25 × 1010 cfu per pot) together with S. thermophilus and L. bulgaricus 1.2 × 109 cfu per pot Health related quality of life Bloating, abdominal pain, global digestive symptom 6 weeks
Gawronska A, 2007, Poland 37
Rome II LGG (Lactobacillus rhamnosus GG) 3 × 109 cfu, twice daily, Self reported abdominal pain 4 weeks
Whorwell PJ, 2006, UK 362
All female
Rome II 3 different strengths treatments
Bifidobacterium (B.) infantis 35624 × 106 live bacterial cells
B. infantis 35624 × 108 live bacterial cells
B. infantis 35624 × 1010 live bacterial cells
Once daily capsule
Global assessment (SGA) of IBS symptoms
Abdominal pain/discomfort, Bloating/distension, passage of gas
4 weeks
Bausserman M, 2005, USA 64
Rome II lactobacillus GG 1010 and Inulin was also present both in treatment and in placebo one capsule twice a day Changes in abdominal pain severity 6 weeks
Niv, 2005, Israel 54
Rome II 1 × 108 cfu of Lactobacillus reuteri ATCC 55730, four tablets to be taken for seven days, followed by a dose of 2 tablets per day until close of the study abdominal pain, quality of life 6 months
Kajander K, 2005, Finland 103
Rome I and Rome II Combination
Lactobacillusrhamnosus GG, Lactobacillus rhamnosus LC 705, Bifidobacterium breve Bb 99 and Propionibacterium freudenreichii ssp. Shemanii JS 8–9 × 109
Abdominal pain, distension, flatulence, borborygmi 6 months
Kim HJ, Vazquez Roque M, 2005, USA 48
Rome II VSL # 3 mixture of bacteria combination twice daily (450 billion viable lyophilized bacteria)
One packet twice a day
Abdominal bloating, flatulence, abdominal pain 8 weeks
O'Mahony L, 2005, Ireland 80
Rome II Either B infantis 35624 Or L. salivarIus UCC 4331 each delivered in a dose of 1 × 10 10
Once Daily
Abdominal pain or discomfort, bloating or distension and bowel movement difficulty
Quality of life assessment using an IBS specific questionnaire
8 weeks
Saggioro A, 2004, Italy Unclear (6–64) Rome II Combination L. plantarum LP01 plus one strain of B. breve BR0
5 × 10 10 cfu/ml once a day
Combination Strain of L. plantarum LP01 plus a strain of L. acidophilus LA02 one strain of B. breve BR0
5 × 109 cfu/ml once a day
Pain score at different locations in RLQ and LLQ of the abdomen
Overall symptom score
4 weeks
Kim HJ, Camilleri M, 2003, USA 25
Rome II
Diarrhea predominant symptom
Combination VSL # 3 mixture of bacteria
One packet twice a day
abdominal pain, bloating, flatulence 8 weeks
Niedzielin K, 2001, Poland 40
Manning Lactobacillus plantarum 299V
5 × 107 CFU/ml twice a day
improvement in pain and flatulence 4 weeks
Nobaek S, 2000, Sweden 60
Rome 400 ml/day of rose hip drink syrup containing 5 × 10 7 cfu/ml of L. plantarum DSM 9843 (strain 299V) and 0.009 g/ml oat flour Overall GI function abdominal pain, flatulence, defecation 4 weeks
O'Sullivan MA, 2000, Ireland 24
Rome Lactobacillus GG 1 × 1010 cfu/day
two tablets twice a day
Abdominal bloating, pain, bowel frequency 20 week
Gade, 1989, Denmark 54
constipation and or diarrheoa, abdominal pain, meteorism, borborygmus and flatulence Paraghurt (freeze dried culture of Streptococcus faecium) 4 tablets morning and evening abdominal pain, meteorism, borborygmus, flatulence 4 weeks
  1. cfu: Colony Forming Unit
  2. Combination denotes a mixture of probiotics