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Table 4 The expression patterns for GATA-4, GATA-6 and Ihh in gastrointestinal neoplasias

From: Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa

Tissue Diagnosis GATA-4 GATA-6 Ihh
Esophagus (n = 9)     
  Barrett's esophagus +++ +++ ++
Stomach (n = 8)     
  Intestinal metaplasia +++ +++ ++
  Neuroendocrine cell hyperplasia ++ +++ -
Colon (n = 15)     
  Adenoma, low grade dysplasia - + +
  Adenoma, high grade dysplasia - ++ ++
  Adenocarcinoma, low/moderate grade - + -
  Adenocarcinoma, high grade - + -
  1. The expression patterns are based on the number of positive cells detected and the intensity of staining:
  2. - no expression
  3. + individual positive cells or small areas with low expression
  4. ++ patches of moderate expression
  5. +++ large areas of moderate or strong expression