GATA-4, GATA-6, and Ihh protein expression in neoplastic gastrointestinal mucosa. GATA-4, GATA-6, and Ihh are strongly expressed in intestinal metaplasia of the stomach (A, A', and A", respectively). The insets in A, A' and A" represent magnifications of cardiac glands. GATA-4 and GATA-6 are strongly expressed in neuroendocrine cell hyperplasia (B and B', respectively) in contrast to no or little expression of Ihh (B"). GATA-4 is detected neither in colon adenomas (C) nor carcinomas (D). The expressions of GATA-6 and Ihh are weak in adenomas, but enhanced in high grade dysplasias (C' and C" with insets). Little GATA-6 is found in the carcinoma tissue (D'). Ihh is not present in colon carcinoma (D"). Scale bar = 50 μm.