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Table 5 Univariate analysis: Clinical and biochemical factors related to cause of iron deficiency anaemia in patients with out gastrointestinal symptoms

From: Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms

  Cause of Iron Deficiency Identified (n = 68) Cause of Iron deficiency not identified (n = 27) Odds ratio 95% CI P value
Clinical variables      
Age (yrs) Mean (SD) 55(14) 44(20) 1.04 1.01 – 1.07 0.004
Age ≥ 55 yrs † 34(50%) 06(22.2%) 3.5 1.2 – 9.7 0.01
NSAID users †† 18(26.5%) 04(14.8%) 2.0 0.6 – 6.8 0.22
Hx of Weight loss ††† 19(27.9%) 10(37.03%) 0.6 0.2 – 1.6 0.38
Hx of Fatigue/Lethargy ¶ 16(23.5%) 02(7.4%) 3.8 0.8 – 18 0.08
Prior Hx of IDA therapy ¶¶ 08(11.8%) 01(3.7%) 3.4 0.4 – 29.1 0.43
Biochemical Variables      
Hb (gm/dl) Mean (SD) 6.9(1.9) 7.3(2.2) 0.9 0.7 – 1.1 0.44
Hb ≤ 9 gm/dl ‡ 57(83.8%) 18(66.7%) 2.5 0.9 – 7.2 0.06
MCV (fl) Mean (SD) 60.0(5.5) 64.0(4.7) 0.8 0.7 – 0.9 0.002
MCV 60 fl ‡‡ 43(63.2%) 03(11.1%) 13.7 3.7 – 50.3 <0.001
Serum Iron (μg/ml) Mean (SD) 11.5(6.5) 11.3(5.1) 1.0 0.9 – 1.0 0.86
Serum Iron ≤ 10 (μg/ml)* 35(51.4%) 15(55.5%) 0.85 0.3 – 2.0 0.71
TIBC (μg/dl) Mean (SD) 399(82) 361(85) 1.0 1.0 – 1.01 0.04
Transferrin saturation (%) Mean (SD) 4.3(2.7) 4.1(2.0) 1.9 0.7 – 4.9 0.67
Ferritin (ng/ml) Mean (SD) 6.0(4.0) 6.1(3.3) 0.99 0.8 – 1.1 0.88
Ferritin ≤ 5 (ng/ml) ** 36(52.9%) 10(37.0%) 1.9 0.7 – 4.7 0.17
FOB (Positive) *** 28(41.2%) 02(7.4%) 8.7 1.9 – 39.9 0.001
  1. Reference groups: †Age <55 yrs; ††No NSAIDS use; ††† No Hx of weight loss; ¶No Hx of Fatigue/Lethargy; ¶¶ No Prior Hx of IDA therapy; Hb > 9 gm/dl; ‡‡ MCV>60 fl; * Serum Iron > 10 (μg/dl); ** Ferritin> 5 (ng/ml); *** FOB (Negative)