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Table 5 Univariate analysis: Clinical and biochemical factors related to cause of iron deficiency anaemia in patients with out gastrointestinal symptoms

From: Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms

 

Cause of Iron Deficiency Identified (n = 68)

Cause of Iron deficiency not identified (n = 27)

Odds ratio

95% CI

P value

Clinical variables

     

Age (yrs) Mean (SD)

55(14)

44(20)

1.04

1.01 – 1.07

0.004

Age ≥ 55 yrs †

34(50%)

06(22.2%)

3.5

1.2 – 9.7

0.01

NSAID users ††

18(26.5%)

04(14.8%)

2.0

0.6 – 6.8

0.22

Hx of Weight loss †††

19(27.9%)

10(37.03%)

0.6

0.2 – 1.6

0.38

Hx of Fatigue/Lethargy ¶

16(23.5%)

02(7.4%)

3.8

0.8 – 18

0.08

Prior Hx of IDA therapy ¶¶

08(11.8%)

01(3.7%)

3.4

0.4 – 29.1

0.43

Biochemical Variables

     

Hb (gm/dl) Mean (SD)

6.9(1.9)

7.3(2.2)

0.9

0.7 – 1.1

0.44

Hb ≤ 9 gm/dl ‡

57(83.8%)

18(66.7%)

2.5

0.9 – 7.2

0.06

MCV (fl) Mean (SD)

60.0(5.5)

64.0(4.7)

0.8

0.7 – 0.9

0.002

MCV 60 fl ‡‡

43(63.2%)

03(11.1%)

13.7

3.7 – 50.3

<0.001

Serum Iron (μg/ml) Mean (SD)

11.5(6.5)

11.3(5.1)

1.0

0.9 – 1.0

0.86

Serum Iron ≤ 10 (μg/ml)*

35(51.4%)

15(55.5%)

0.85

0.3 – 2.0

0.71

TIBC (μg/dl) Mean (SD)

399(82)

361(85)

1.0

1.0 – 1.01

0.04

Transferrin saturation (%) Mean (SD)

4.3(2.7)

4.1(2.0)

1.9

0.7 – 4.9

0.67

Ferritin (ng/ml) Mean (SD)

6.0(4.0)

6.1(3.3)

0.99

0.8 – 1.1

0.88

Ferritin ≤ 5 (ng/ml) **

36(52.9%)

10(37.0%)

1.9

0.7 – 4.7

0.17

FOB (Positive) ***

28(41.2%)

02(7.4%)

8.7

1.9 – 39.9

0.001

  1. Reference groups: †Age <55 yrs; ††No NSAIDS use; ††† No Hx of weight loss; ¶No Hx of Fatigue/Lethargy; ¶¶ No Prior Hx of IDA therapy; Hb > 9 gm/dl; ‡‡ MCV>60 fl; * Serum Iron > 10 (μg/dl); ** Ferritin> 5 (ng/ml); *** FOB (Negative)