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Table 3 Univariate analysis: Clinical and biochemical factors related to bleeding lesions on endoscopy

From: Predictors of gastrointestinal lesions on endoscopy in iron deficiency anemia without gastrointestinal symptoms

  Endoscopic lesions Identified (n = 51) No endoscopic lesions Identified (n = 44) Odds ratio 95%CI P value
Clinical variables      
Age (yrs) Mean (SD) 57.3(14.5) 49.3(17.4) 1.04 1.01 – 1.07 <0.001
Age ≥ 55 yrs † 30(58.8%) 10 (22.7%) 4.8 1.9 – 11.9 <0.001
NSAID users †† 16(31.4%) 06(13.6%) 2.8 1.0 – 8.2 0.04
Hx of Weight loss ††† 16(31.4%) 13(29.5%) 1.0 0.4 – 2.6 0.84
Hx of Fatigue/Lethargy ¶ 13(25.5%) 05(11.4%) 2.6 0.8 – 8.2 0.11
Prior Hx of IDA therapy ¶¶ 07(13.7%) 02(4.5%) 3.3 0.6 – 0.9 0.14
Biochemical Variables      
Hb≤ (gm/dl) Mean (SD) 6.6(1.9) 7.5(2.1) 0.8 0.6 – 0.9 0.04
Hb ≤ 9 gm/dl ‡ 46(90.2%) 29(65.9%) 4.7 1.5 – 14.4 0.004
MCV (fl) Mean (SD) 60.3(5.6) 62.2(5.6) 0.9 0.8 – 1.0 0.1
MCV ≤ 60 fl ‡‡ 32(62.7%) 14(31.8%) 3.6 1.5 – 8.4 0.003
Serum Iron (μg/dl) Mean(SD) 10.5(6.8) 12.5(5.1) 0.9 0.8 – 1.0 0.13  
Serum Iron ≤ 10 (μg/dl) * 31(60%) 19(43.0%) 2.0 0.8 – 4.6 0.08  
TIBC (μg/dl) Mean (SD) 396(88) 379(79) 1.0 0.9 – 1.0 0.33  
Transferrin saturation (%) Mean (SD) 4.4(4.4) 4.1(4.1) 1.0 0.9 – 1.2 0.47  
Ferritin (ng/ml) Mean (SD) 6.3(4.2) 5.8(3.3) 1.03 0.9 – 1.1 0.54  
Ferritin ≤ 5 (ng/ml) ** 28(54.9%) 18(40.9%) 1.75 0.7 – 3.9 0.17  
FOB (Positive) *** 27(52.9%) 03(6.8%) 15.3 4.2 – 56.1 <0.001
  1. Reference groups: †Age <55 yrs; ††No NSAIDS use; ††† No Hx of weight loss; ¶No Hx of Fatigue/Lethargy; ¶¶ No Prior Hx of IDA therapy; Hb > 9 gm/dl; ‡‡ MCV>60 fl; * Serum Iron > 10 (μg/dl); ** Ferritin> 5 (ng/ml); *** FOB (Negative)