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Figure 4 | BMC Gastroenterology

Figure 4

From: Epigenetic mechanisms involved in differential MDR1mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy

Figure 4

Comparison of Pgp expression and function in gastric and colon cancer cell lines. (A) Comparative sensitivity of Colo320HSR (colon, highest), SNU-668 (gastric, highest) and SNU-C5 (colon, no expression) to paclitaxel; (B) Effects of Pgp inhibitors on the sensitivity of Colo320HSR, SNU-668 and SNU-C5 to paclitaxel (IC10 concentration; 50 μM, 0.3 nM and 0.5 nM, respectively). Sensitivity to paclitaxel was determined using MTT assay in the presence or absence of the Pgp inhibitors (cyclosporin A, verapamil and PSC833 of 0.8 μM each). *, P <0.05 versus the control.

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