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Table 3 Mortality in patients with unexplained chest/epigastric pain (UCEP).

From: Unexplained chest/epigastric pain in patients with normal endoscopy as a predictor for ischemic heart disease and mortality: A Danish 10-year cohort study

 

UCEP patients*

(N = 386), n (%)

Population controls**

(N = 3,793), n (%)

Crude MRR

Adjusted MRR†

Total deaths

62 (16)

508 (13)

1.2 (1.0–1.6)

1.1 (0.9–1.5)

Time to death after upper endoscopy

    

   <1 year

10 (3)

40 (1)

2.7 (1.5–5.0)

2.4 (1.3–4.5)

   1–2 years

14 (4)

83 (2)

1.9 (0.9–4.3)

1.7 (0.8–3.9)

   3–4 years

6 (2)

93 (2)

1.0 (0.6–1.8)

0.9 (0.6–1.6)

   ≥ 5 years

32 (8)

292 (8)

1.0 (0.7–1.5)

0.9 (0.6–1.4)

Cause-specific deaths

    

   Deaths from ischemic heart disease‡

8 (2)

76 (2)

1.1 (0.5–2.2)

1.1 (0.5–2.2)

   Deaths from arteriosclerosis (not ischemic heart disease, not stroke)

4 (1)

51 (1)

0.8 (0.3–2.1)

0.7 (0.3–2.1)

   Deaths from pneumonia

12 (3)

41 (1)

2.8 (1.5–5.4)

2.7 (1.4–5.2)

   Deaths from stroke

4 (1)

34 (1)

1.1 (0.4–3.1)

1.1 (0.4–3.2)

   Deaths from lung cancer

5 (1)

27 (1)

1.9 (0.7–4.9)

1.7 (0.6–4.4)

   Deaths from alcohol dependence§

3 (1)

5 (0.1)

3.4 (0.7–16.8)

1.5 (0.3–8.2)

   Deaths from chronic obstructive pulmonary disease¶

3 (1)

38 (1)

0.7 (0.2–2.4)

0.8 (0.2–2.5)

  1. Crude and adjusted mortality rate ratios (MRR) and 95% confidence intervals for patients with unexplained chest/epigastric pain (UCEP) compared with population controls, overall, time-dependent, and by cause of death.
  2. * Normal upper endoscopy and no discharge diagnoses of ischemic heart disease before study entry.
  3. ** No discharge diagnoses of ischemic heart disease before study entry.
  4. † Adjusted for alcohol- and smoking-related diseases, and Charlson comorbidity Index: no comorbidity (Charlson Index 0), comorbidity level 1 (Charlson. Index 1–2) and comorbidity level 2 (Charlson Index > 2).
  5. ‡ Myocardial infarction, angina, and/or heart failure.
  6. § Not adjusted for alcohol-related diseases.
  7. ¶ Not adjusted for smoking-related disease.