The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the Apc Min/+mouse small intestine

Table 2 Tumorigenesis in the small intestine of outwardly healthy Apc ^Min/+, K-ras ^+/+ and Apc ^Min/+, K-ras ^{tmΔ4A/tmΔ4A} mice

Genotype	Sex	Mice per cohort	Age (days) ± SEM	Tumour number ± SEM	Tumour area (mm²) ± SEM
Stocks culled at ≅ 106 days
Apc ^Min/+, K-ras ^+/+	M	4	108.3 ± 1.0	36.3 ± 7.9^a	43.5 ± 9.4ⁱ
Apc ^Min/+, K-ras ^+/+	F	4	104.5 ± 1.5	59.0 ± 2.9^b	74.3 ± 8.8^j
Apc ^Min/+, K-ras ^{tmΔ4A/tmΔ4A}	M	6	107.2 ± 0.5	51.5 ± 16.2^c	68.8 ± 23.1^k
Apc ^Min/+, K-ras ^{tmΔ4A/tmΔ4A}	F	4	105.5 ± 0.5	36.5 ± 15.3^d	57.0 ± 29.8^l
Stocks culled at ≅ 152 days
Apc ^Min/+, K-ras ^+/+	M	10	152.0 ± 0.9	56.8 ± 8.8^e	131.0 ± 19.6^m
Apc ^Min/+, K-ras ^+/+	F	4	151.8 ± 1.3	46.3 ± 5.9^f	89.8 ± 10.9ⁿ
Apc ^Min/+, K-ras ^{tmΔ4A/tmΔ4A}	M	3	153.3 ± 1.3	35.3 ± 7.5^g	99.0 ± 20.0^o
Apc ^Min/+, K-ras ^{tmΔ4A/tmΔ4A}	F	9	151.1 ± 2.8	61.3 ± 9.7^h	118.7 ± 22.3^p

M, male; F, female. ^a vs. ^c P = 0.42;^b vs. ^d P = 0.20; ^e vs. ^g P = 0.090;^f vs. ^h P = 0.21; ⁱ vs. ^k P = 0.34;
^j vs. ^l P = 0.60; ^m vs. ^o P = 0.28; ⁿ vs. ^p P = 0.27 (Student's t-test in each case).

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