Time esophageal pH < 4 overestimates the prevalence of pathologic esophageal reflux in subjects with gastroesophageal reflux disease treated with proton pump inhibitors

Table 4 Prevalence of Pathologic Esophageal Reflux Stratified by Nocturnal Gastric Breakthrough.

	Index Study
	NAB (n = 34)		No NAB (n = 12)
Pathologic Nocturnal Esophageal Acid	Integrated Acidity	Time pH < 4	Integrated Acidity	Time pH < 4
YES	7	18	0	3
NO	27	16	12	9
	3 ^rd Study
	NAB (n = 140)		No NAB (n = 16)
Pathologic Nocturnal Esophageal Acid	Integrated Acidity	Time pH < 4	Integrated Acidity	Time pH < 4
YES	49	97	1	9
NO	91	43	15	7

ISSN: 1471-230X