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Table 1 Cut-points, Sensitivities, Specificities and ROC Areas for Pathologic Integrated Esophageal Acidity and Time Esophageal pH < 4.

From: Time esophageal pH < 4 overestimates the prevalence of pathologic esophageal reflux in subjects with gastroesophageal reflux disease treated with proton pump inhibitors

Period

Integrated Acidity (mmol.hr/L)

Time pH < 4(%)

Cut-point

8.1

4.3

24-hour (900–900)

  

Sensitivity (%)

72

89

Specificity (%)

88

81

ROC Area

0.86 [0.77,0.94]

0.90 [0.84, 0.97]

Postprandial (900–2200)

  

Cut-point

1.85

6.8

Sensitivity (%)

92

85

Specificity (%)

62

85

ROC Area

0.82 [0.72, 0.91]

0.88 [0.80, 0.95]

Nocturnal (2200–900)

  

Cut-point

1.3

2.1

Sensitivity (%)

79

81

Specificity (%)

77

85

ROC Area

0.79 [0.69, .90]

0.84 [0.74, .92]

  1. Results are from 26 normal and 57 GERD subjects. Values in brackets for ROC area are the 95 % confidence intervals.