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Table 1 Cut-points, Sensitivities, Specificities and ROC Areas for Pathologic Integrated Esophageal Acidity and Time Esophageal pH < 4.

From: Time esophageal pH < 4 overestimates the prevalence of pathologic esophageal reflux in subjects with gastroesophageal reflux disease treated with proton pump inhibitors

Period Integrated Acidity (mmol.hr/L) Time pH < 4(%)
Cut-point 8.1 4.3
24-hour (900–900)   
Sensitivity (%) 72 89
Specificity (%) 88 81
ROC Area 0.86 [0.77,0.94] 0.90 [0.84, 0.97]
Postprandial (900–2200)   
Cut-point 1.85 6.8
Sensitivity (%) 92 85
Specificity (%) 62 85
ROC Area 0.82 [0.72, 0.91] 0.88 [0.80, 0.95]
Nocturnal (2200–900)   
Cut-point 1.3 2.1
Sensitivity (%) 79 81
Specificity (%) 77 85
ROC Area 0.79 [0.69, .90] 0.84 [0.74, .92]
  1. Results are from 26 normal and 57 GERD subjects. Values in brackets for ROC area are the 95 % confidence intervals.