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Table 2 Expression of transcription factors and differentiation markers in tissue samples from EGDA rats and humans

From: Multilayered epithelium in a rat model and human Barrett's esophagus: Similar expression patterns of transcription factors and differentiation markers

Antigen EGDA Rat Samples
No. of positively stained foci/No. of total foci (%)
Human Biopsy Samples
No. of positively stained foci/No. of total foci (%)
  Squamous epithelium MLE Intestinal metaplasia Squamous epithelium MLE Intestinal metaplasia
p63a 128/128 (100%) 85/85 (100%) 0/142 (0%) 11/11 (100%) 5/13 (38.5%) 0/3 (0%)
Sox2 114/114 (100%) 71/71 (100%) 0/128 (0%) 11/11 (100%) 13/13 (100%) 0/3 (0%)
CK14a 113/113 (100%) 76/76 (100%) 0/139 (0%) 11/11 (100%) 0/13 (0%) 0/3 (0%)
CK4 116/116 (100%) 30/55 (54.5%) 0/129 (0%) 11/11 (100%) 4/13 (30.8%) 0/3 (0%)
Cdx2 0/114 (0%) 0/77 (0%) 127/127 (100%) 0/11 (0%) 2/13 (15.4%) 3/3 (100%)
GATA4 0/114 (0%) 0/70 (0%) 130/130 (100%) 0/11 (0%) 0/13 (0%) 2/3 (66.7%)
HNF1α 0/100 (0%) 0/54 (0%) 111/111 (100%) N/A N/A N/A
Villin 0/115 (0%) 15/56 (26.8%) 133/133 (100%) 0/11 (0%) 2/13 (15.4%) 3/3 (100%)
Muc2 0/114 (0%) 0/75 (0%) 129/129 (100%) 0/11 (0%) 0/13 (0%) 3/3 (100%)
  1. a Statistically significant difference between rat and human MLE (p < 0.0001).