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Figure 3 | BMC Gastroenterology

Figure 3

From: Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4agonist – tegaserod

Figure 3

Antagonism of nicotinic receptors and contractions of the longitudinal muscle of the jejunum. Absence of an effect of the nicotinic receptor antagonist, hexamethonium (10-5M) on cholinergic contractions of the jejunum of vehicle-treated ground squirrel fed either a low (0.027%; A) or a high (1%; B) cholesterol diet. Hexamethonium was added to the jejunal tissue segments 10 min before constructing a cumulative dose-response curve to the cholinergic agonist, carbachol. N = 5–6.

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