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Figure 2 | BMC Gastroenterology

Figure 2

From: Increased cholinergic contractions of jejunal smooth muscle caused by a high cholesterol diet are prevented by the 5-HT4agonist – tegaserod

Figure 2

Action potential blockade and contractions of the longitudinal muscle of the jejunum. Effects of tetrodotoxin (TTX) on cholinergic contractions of the jejunum of ground squirrel fed either a low (0.027%; A & C) or a high (1%; B & D) cholesterol diet. The animals were treated with either vehicle (A & B) or tegaserod (C & D). The action potential blocker tetrodotoxin (TTX; 10-7M) was added to the jejunal tissue segments 10 min before constructing a cumulative dose-response curve to the cholinergic agonist, carbachol. * TTX greater than No TTX (P < 0.05). N = 8–9.

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