Table 5 Sensitivity analyses of FibroTest for the diagnosis of advanced fibrosis (F2F3F4) [Area under the ROC curves (AUROCs)], according to group, ALT values, alcohol consumption, exclusion of high risk of FibroTest failures, quality of biopsy and repeated biopsies

All patients

267

0.81

0.74

0.86

0.27

Stratified according to Group

Group 1

170

0.86

0.77

0.91

0.24

Group 2

97

0.75

0.61

0.83

0.32

Stratified according to ALT value

ALT<50IU/L

99

0.80°

0.65

0.90

0.24

ALT>= 50 IU/L

168

0.81

0.72

0.87

0.28

Stratified according to Alcohol consumption

<30 g for men and <20 g for female

243

0.82 $

0.74

0.87

0.32

30–40 g for men or 20–25 g for female

24

0.71

0.66

0.84

0.24

High risk of FibroTest failures excluded

Gilbert excluded

263

0.82

0.75

0.88

0.26

Acute Inflammation excluded

263

0.82

0.75

0.87

0.26

Gilbert or Acute Inflammation excluded

258

0.83

0.76

0.88

0.26

Quality of biopsy

<25 mm

202

0.80 *

0.72

0.86

0.29

>= 25 mm

65

0.85

0.66

0.94

0.20

Fragmented

152

0.81 £

0.67

0.89

0.29

Not fragmented

115

0.81

0.71

0.87

0.23

Patients with 2 biopsies

First biopsy

47

0.87

0.71

0.95

0.34

Second biopsy

47

0.90

0.75

0.96

0.32

Mean 2 biopsies

47

0.91

0.76

0.97

0.32