Table 2 Univariate and multivariate predictors of advanced fibrosis
Characteristic | Group 1 | Group 2 | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
All patients included | ||||||||
F0-F1 n = 130 | F2-F4 n = 40 | P-value | F0-F1 N = 66 | F2-F4 N = 31 | P-value | Odds Ratio (95% CI) N = 267 | P-value | |
Age years | 50.4 (1.0) | 60.4 (1.4) | <0.0001 | 5.3 (1.4) | 55.4 | <0.0001 | 1.07 (1.03–1.10) | <0.0001 |
Male | 78 (60%) | 20 (50%) | 0.26 | 39 (59%) | 18 (58%) | 0.92 | 0.83 (0.47–1.64) | 0.59 |
Markers α2-macro g/L | 1.52 (0.05) | 2.22 (0.13) | <0.0001 | 1.56 (0.06) | 2.04 (0.14) | 0.007 | 3.74 (2.2–6.5) | P < 0.0001 |
ALT IU/L | 73 (4) | 66 (7) | 0.30 | 73 (6) | 91 (10) | 0.09 | 1.00 (0.99–1.01) | 0.10 |
AST IU/L | 46 (2) | 64 (10) | 0.25 | 36 (2) | 64 (7) | <0.0001 | 1.03 (1.01–1.05) | 0.01 |
ApoA1 g/L | 1.48 (0.03) | 1.43 (0.06) | 0.99 | 1.63 (0.10) | 1.49 (0.05) | 0.26 | 0.32 (0.10–0.99) | 0.048 |
Haptoglobin g/L | 1.12 (0.04) | 1.05 (0.10) | 0.20 | 1.17 (0.13) | 1.01 (0.10) | 0.42 | 0.81 (0.45–1.46) | 0.47 |
GGT IU/L | 95 (10) | 158 (34) | 0.09 | 131 (14) | 132 (23) | 0.87 | 1.01 (1.01–1.01) | 0.01 |
Bilirubin, μmol/L | 10.7 (0.5) | 26.9 (13.2) | 0.003 | 12.6 (0.7) | 12.5 (1.0) | 0.89 | 1.06 (1.01–1.11 | 0.03 |
FibroTest | 0.23 (0.01) | 0.51 (0.03) | <0.0001 | 0.24 (0.02) | 0.41 (0.04) | <0.0001 | 439 (73–2640)* | <0.0001 |
ActiTest | 0.37 (0.02) | 0.43 (0.03) | 0.11 | 0.37 (0.02) | 0.50 (0.04) | 0.004 | 0.94 (0.19–4.73)* | 0.93 |