Skip to main content

Table 4 Allele frequency and genotype distribution of I/D polymorphism at ACE locus in TCP patients and controls based on their N34S SPINK1 status

From: Lack of significant association of an insertion/deletion polymorphism in the angiotensin converting enzyme (ACE) gene with tropical calcific pancreatitis

  Patients Controls
  TCP P Value FCPD P Value Total P Value   
N34S SPINK1 mutation status Mutant* Wild   Mutant# Wild   Mutant Wild   Mutant$ Wild
N 31 60   21 59   52 119   3 96
Allele frequency            
   I 0.60 0.54 0.39 0.55 0.51 0.57 0.58 0.53 0.48 0.67 0.53
   D 0.40 0.46   0.45 0.49   0.42 0.47   0.33 0.47
Genotype frequency based on the presence or absence of the mutant allele            
   II 0.36 (11) 0.32 (19) 0.55 0.29 (06) 0.22 (13) 0.26 0.33 (17) 0.27 (32) 0.35 0.33 (01) 0.26 (25)
   ID + DD 0.64 (20) 0.68 (41)   0.71 (15) 0.78 (46)   0.67 (35) 0.73 (87)   0.67 (02) 0.74 (71)
  1. n, number of individuals; TCP, tropical calcific pancreatitis; FCPD, fibro-calculous pancreatic diabetes; ACE, angiotensin converting enzyme; I/D, insertion/deletion polymorphism at ACE locus figures in parentheses indicate number of individuals; P value is represented on comparison of N34S SPINK1 positive vs. N34S negative TCP, FCPD and total patients.
  2. *, includes 9 N34S SPINK1 homozygotes and 22 heterozygotes; # includes 4 N34S SPINK1 homozygotes and 17 heterozygotes, $, includes 3 N34S SPINK1 heterozygotes