Table 1 patient characteristics:
Characteristics | Group 1 Furosemide 40 mg (n = 8) | Group 2 Furosemide1 120 mg (n = 10) | P value |
|---|---|---|---|
Age (years) | 56.5 ± 9.6 | 54 ± 9.0 | NS |
Sex ratio (M/F) | 5/3 | 6/4 | NS |
Etiology : Alcoholic | 3 | 4 | NS |
Non alcoholic | 5 | 6 | NS |
Serum albumin(g/L) | 39 ± 4 | 40 ± 5 | NS |
INR | 1.09 ± 0.1 | 1.1 ± 0.1 | NS |
Bilirubin (micromol/L) | 20.5 ± 34.9 | 18.8 ± 8.5 | NS |
Child-Pugh's score | 5–6 | 5–6 | NS |
MELD score | 7 | 8 | NS |
Serum sodium(mEq/L) | 136 ± 1.0 | 137 ± 1.6 | NS |
Median (range) | 136 (134–138) | 136 (133–139) | |
Serum creatinine (micromol/L) | |||
Base line | 77.8 ± 14 | 81.3 ± 15 | NS |
After 1 week follow up | 79.6 ± 13 | 82.2 ± 16.8 | NS |
Creatinine clearance (ml/min) | 82.6 ± 30.4 | 89.8 ± 32.0 | NS |
Median (range) | 73 (56–142) | 92 (41–150) | |
8-hours UNa (before, median, range) | 87 ± 26 (80, 60–122) | 97 ± 32 (107, 37–128) | NS |
8-hours UNa (After mEq, median, range) | 100 ± 36 (96,42–147) | 136 ± 37 (127, 92–213) | 0.05 |
% Change | +15% | +40% | 0.01 |
DMSA Uptake (Nl > 20%) | |||
Before Furosemide (median, range) | 12.8 ± 3.8 (14, 3–17) | 10.6 ± 4.6 (10, 3–21) | 0.001 |
After Furosemide (median, range) | 15.2 ± 2.2 (16, 10–20) | 13.5 ± 3.6 (15, 6–21) | 0.001 |
% Change | +19% | +27% | |
p < 0.001 | p = <0.003 |