Table 6 Sensitivity analyses of NashTest for the diagnosis of Nash versus No Nash or Borderline Nash [Area under the ROC curves (AUROCs)], according to group, ALT values, alcohol consumption, quality of biopsy, inclusion of patients without steatosis, and exclusion of high risk of biomarkers failures.

All 257 patients

257

0.75

0.67

0.82

0.25

Stratified according to Group*

Training Group

160

0.79

0.69

0.86

0.18

0.94

Validation Group

97

0.79

0.67

0.87

0.36

Stratified according to ALT value*

ALT < 50 IU/L

92

0.78

0.58

0.89

0.17

0.58

ALT >= 50 IU/L

165

0.73

0.64

0.81

0.28

Stratified according to Alcohol consumption*

None

95

0.72

0.57

0.82

0.31

0.78 and 0.28

< 30 g for men and < 20 g for female

150

0.77

0.66

0.84

0.19

0.78 and 0.33

>= 30 g for men or >= 20 g for female

12

0.94

0.53

0.99

0.50

0.28 and 0.33

Quality of biopsy*

< 25 mm

194

0.76

0.66

0.83

0.25

0.72

>= 25 mm

63

0.73

0.55

0.84

0.24

Fragmented

148

0.71

0.58

0.80

0.22

0.15

Not Fragmented

109

0.81

0.70

0.88

0.28

Patients included or excluded

Patients without steatosis included**

277

0.76

0.68

0.82

0.39

0.85

High risk of NashTest failures excluded**

Gilbert excluded

244

0.76

0.68

0.82

0.25

0.78

Acute Inflammation excluded

254

0.75

0.67

0.82

0.24

0.95