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Table 3 Univariate and multivariate predictors of NASH in the overall population (training and validation groups together)

From: Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease

Characteristic     No NASH vs Borderline or NASH NASH vs Borderline or No NASH
  No NASH n = 98 Borderline NASH n = 96 NASH n = 63 Univariate analysis P-value Multivariate analysis P value Odds Ratio (95% CI) Univariate analysis P-value Multivariate analysis P value Odds Ratio (95% CI)
Demographics          
   Age at biopsy, years 49.4 (1.2) 51.4 (1.2) 53.8 (1.5) 0.045 0.75 1.00 (0.97;1.04) 0.04 0.99 1.00 (0.97;1.33)
   Male gender 56/98 (57%) 66/96 (69%) 31/63 (49%) 0.54 0.82 1.10 (0.48;2.56) 0.054 0.04 2.54 (1.03;6.26)
   Weight, kg 75.2 (1.4) 86.8 (1.4) 82.3 (1.8) < 0.0001 < 0.0001 1.06 (1.03;1.08) 0.25 0.86 1.00 (0.97;1.02)
   Height, meter 1.68 (0.01) 1.69 (0.01) 1.67 (0.01) 0.87 0.15 0.03 (0.00;3.34) 0.22 0.66 0.33 (0.00;47.2)
Biochemical markers          
   α2-macroglobulin, g/L 1.58 (0.07) 1.73 (0.07) 1.86 (0.08) 0.02 0.15 0.33 (0; 1050) 0.01 0.16 0.72 (0.46;1.14)
   ALT, IU/L 67 (5) 74 (5) 88 (6) 0.005 0.90 1.00 (0.99;1.01) 0.004 0.24 0.99 (0.99;1.00)
   AST, IU/L 40 (3) 48 (3) 60 (4) 0.0004 0.007 1.02 (1.01;1.04) 0.001 0.25 0.99 (0.98;1.01)
   Apolipoprotein A1, g/L 1.61 (0.05) 1.43 (0.05) 1.50 (0.06) 0.08 0.27 0.53 (0.17;1.67) 0.62 0.71 1.14 (0.57;2.28)
   Haptoglobin, g/L 1.14 (0.10) 1.11 (0.07) 1.02 (0.09) 0.87 0.50 0.83 (0.47;1.44) 0.41 0.18 1.56 (0.81;2.99)
   GGT, IU/L 133 (14) 98 (14) 128 (17) 0.002 0.005 1.00 (0.993;0.998) 0.48 0.37 1.00 (0.998;1.00)
   Total bilirubin, μmol/L 11.2 (0.6) 12.0 (0.6) 12.5 (0.8) 0.87 0.22 1.04 (0.98;1.09) 0.30 0.35 0.98 (0.93;1.02)
   Glucose mmol/L 5.5 (0.2) 6.0 (0.2) 7.2 (0.3) 0.005 0.05 1.20 (0.999;1.45) < 0.0001 0.0009 0.77 (0.67;0.90)
   Cholesterol mmol/L 5.4 (0.1) 5.5 (0.1) 5.4 (0.2) 0.68 0.25 1.17 (0.90;1.53) 0.77 0.95 1.01 (0.78;1.30)
   Triglycerides 1.4 (0.2) 2.0 (0.2) 2.0 (0.2) < 0.0001 0.23 1.19 (0.90;1.57) 0.007 0.90 1.01 (0.83;1.24)
FibroTest 0.25 (0.02) 0.31 (0.01) 0.35 (0.02) 0.03 Not included Not included 0.008 Not included Not included
SteatoTest 0.60 (0.02) 0.70 (0.02) 0.72 (0.03) < 0.0001 Not included Not included 0.007 Not included Not included
  1. All data are means (se) and proportions (n [%]). ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl-transpeptidase.