Table 2 Univariate predictors of NASH in training and validation groups

Demographics

   Age at biopsy, years

53.7 (1.5)

52.6 (1.3)

54.2 (2.1)

0.80

44.8 (1.8)

47.3 (2.8)

53.6 (2.1)

0.008

   Male gender

35 (61%)

49 (65%)

12 (43%)

0.11

21 (51%)

17 (81%)

19 (54%)

0.06

   Weight, kg

79.3 (1.9)

86.8 (1.69)

83.9 (2.8)

0.02

69.7 (2.0)

86.6 (2.78)

81.1 (2.15)

< 0.0001

   Height, meter

1.69 (0.01)

1.68 (0.01)

1.66 (0.02)

0.54

1.67 (0.01)

1.74 (0.02)

1.68 (0.02)

0.02

Biochemical markers

   α₂-macroglobulin, g/L

1.61 (0.09)

1.69 (0.08)

1.90 (0.13)

0.18

1.54 (0.10)

1.87 (0.14)

1.83 (0.11)

0.06

   ALT, IU/L

61 (6)

78 (5)

81 (8)

0.03

75 (8)

60 (10)

94 (8)

0.03

   AST, IU/L

42 (4)

53 (4)

57 (6)

0.06

37 (4)

32 (6)

62 (5)

< 0.0001

   Apolipoprotein A1, g/L

1.54 (0.04)

1.41 (0.04)

1.49 (0.06)

0.08

1.71 (0.10)

1.48 (0.15)

1.51 (0.11)

0.32

   Haptoglobin, g/L

1.08 (0.07)

1.14 (0.06)

1.01 (0.10)

0.52

1.24 (0.15)

1.02 (0.21)

1.04 (0.16)

0.56

   GGT, IU/L

107 (19)

103 (17)

139 (28)

0.54

169 (18)

78 (26)

120 (20)

0.02

   Total bilirubin, μmol/L

10.6 (0.9)

11.9 (0.7)

11.6 (1.2)

0.50

12.0 (0.89)

12.6 (1.24)

13.2 (0.96)

0.69

   Glucose mmol/L

5.7 (0.3)

6.1 (0.3)

7.0 (0.4)

0.051

5.2 (0.31)

5.8 (0.44)

7.3 (0.34)

< 0.0001

   Cholesterol mmol/L

5.5 (0.2)

5.4 (0.2)

5.5 (0.2)

0.98

5.4 (0.21)

5.62 (0.29)

5.25 (0.23)

0.61

   Triglycerides

1.6 (0.2)

2.1 (0.2)

2.4 (0.4)

0.16

1.15 (0.11)

1.52 (0.16)

1.67 (0.12)

0.008

FibroTest

0.26 (0.03)

0.31 (0.02)

0.35 (0.04)

0.18

0.23 (0.03)

0.32 (0.04)

0.35 (0.03)

0.02

SteatoTest

0.64 (0.02)

0.72 (0.02)

0.75 (0.03)

0.007

0.54 (0.03)

0.61 (0.05)

0.69 (0.04)

0.02