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Table 2 Univariate predictors of NASH in training and validation groups

From: Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease

Characteristic Training Group Validation Group
  No NASH n = 57 Borderline NASH n = 75 NASH n = 28 P-value No NASH n = 41 Borderline NASH n = 21 NASH n = 35 P-value
Demographics         
   Age at biopsy, years 53.7 (1.5) 52.6 (1.3) 54.2 (2.1) 0.80 44.8 (1.8) 47.3 (2.8) 53.6 (2.1) 0.008
   Male gender 35 (61%) 49 (65%) 12 (43%) 0.11 21 (51%) 17 (81%) 19 (54%) 0.06
   Weight, kg 79.3 (1.9) 86.8 (1.69) 83.9 (2.8) 0.02 69.7 (2.0) 86.6 (2.78) 81.1 (2.15) < 0.0001
   Height, meter 1.69 (0.01) 1.68 (0.01) 1.66 (0.02) 0.54 1.67 (0.01) 1.74 (0.02) 1.68 (0.02) 0.02
Biochemical markers         
   α2-macroglobulin, g/L 1.61 (0.09) 1.69 (0.08) 1.90 (0.13) 0.18 1.54 (0.10) 1.87 (0.14) 1.83 (0.11) 0.06
   ALT, IU/L 61 (6) 78 (5) 81 (8) 0.03 75 (8) 60 (10) 94 (8) 0.03
   AST, IU/L 42 (4) 53 (4) 57 (6) 0.06 37 (4) 32 (6) 62 (5) < 0.0001
   Apolipoprotein A1, g/L 1.54 (0.04) 1.41 (0.04) 1.49 (0.06) 0.08 1.71 (0.10) 1.48 (0.15) 1.51 (0.11) 0.32
   Haptoglobin, g/L 1.08 (0.07) 1.14 (0.06) 1.01 (0.10) 0.52 1.24 (0.15) 1.02 (0.21) 1.04 (0.16) 0.56
   GGT, IU/L 107 (19) 103 (17) 139 (28) 0.54 169 (18) 78 (26) 120 (20) 0.02
   Total bilirubin, μmol/L 10.6 (0.9) 11.9 (0.7) 11.6 (1.2) 0.50 12.0 (0.89) 12.6 (1.24) 13.2 (0.96) 0.69
   Glucose mmol/L 5.7 (0.3) 6.1 (0.3) 7.0 (0.4) 0.051 5.2 (0.31) 5.8 (0.44) 7.3 (0.34) < 0.0001
   Cholesterol mmol/L 5.5 (0.2) 5.4 (0.2) 5.5 (0.2) 0.98 5.4 (0.21) 5.62 (0.29) 5.25 (0.23) 0.61
   Triglycerides 1.6 (0.2) 2.1 (0.2) 2.4 (0.4) 0.16 1.15 (0.11) 1.52 (0.16) 1.67 (0.12) 0.008
FibroTest 0.26 (0.03) 0.31 (0.02) 0.35 (0.04) 0.18 0.23 (0.03) 0.32 (0.04) 0.35 (0.03) 0.02
SteatoTest 0.64 (0.02) 0.72 (0.02) 0.75 (0.03) 0.007 0.54 (0.03) 0.61 (0.05) 0.69 (0.04) 0.02
  1. All data are means (se) and proportions (n [%]). ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, γ-glutamyl-transpeptidase.