Table 5 Multivariate analysis of significant clinical, pathological, and immunohistochemical features influencing the DFS and OS in 85 patients with malignant GISTs of the small intestine who underwent curative resection
Variable | Relative risk | 95% CI for relative risk | P value |
|---|---|---|---|
DFS | |||
Tumor size (2–5, 5–10, and >10 cm) | NS | ||
Local invasion | NS | ||
Tumor perforation | NS | ||
Mitotic count >5 per 50 HPF | 11.36 | 2.653–50.0 | 0.001 |
High cellularity | 2.004 | 1.036–3.876 | 0.039 |
Tumor necrosis | NS | ||
Ki-67 index | 3.460 | 1.1.195 | 0.049 |
OS | |||
Tumor size (2–5, 5–10, and >10 cm) | NS | ||
Tumor perforation | 3.058 | 1.20–7.81 | 0.019 |
Mitotic count >5 per 50 HPF | 6.711 | 1.50–30.30 | 0.013 |
High cellularity | 2.370 | 1.11–5.08 | 0.026 |
Tumor necrosis | NS | ||
Vascular proliferation | NS | ||
Lymphatic infilatration | NS | ||
Ki-67 index ≧10% | NS | ||