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Table 5 Multivariate analysis of significant clinical, pathological, and immunohistochemical features influencing the DFS and OS in 85 patients with malignant GISTs of the small intestine who underwent curative resection

From: Surgical treatment and prognostic analysis for gastrointestinal stromal tumors (GISTs) of the small intestine: before the era of imatinib mesylate

Variable Relative risk 95% CI for relative risk P value
DFS
Tumor size (2–5, 5–10, and >10 cm)    NS
Local invasion    NS
Tumor perforation    NS
Mitotic count >5 per 50 HPF 11.36 2.653–50.0 0.001
High cellularity 2.004 1.036–3.876 0.039
Tumor necrosis    NS
Ki-67 index 3.460 1.1.195 0.049
OS
Tumor size (2–5, 5–10, and >10 cm)    NS
Tumor perforation 3.058 1.20–7.81 0.019
Mitotic count >5 per 50 HPF 6.711 1.50–30.30 0.013
High cellularity 2.370 1.11–5.08 0.026
Tumor necrosis    NS
Vascular proliferation    NS
Lymphatic infilatration    NS
Ki-67 index 10%    NS
  1. DFS = disease-free survival; OS = overall survival; GISTs = gastrointestinal stromal tumors; CI = confidence interval