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Table 3 Prognostic analysis of DFS and OS for GISTs of the small intestine in terms of histopathological features

From: Surgical treatment and prognostic analysis for gastrointestinal stromal tumors (GISTs) of the small intestine: before the era of imatinib mesylate

Variable   Mean DFS (months; 95%CI of mean) P Mean OS (months; 95%CI of mean) P
Cell type Spindle (N = 71) 75.1 (52.9–97.3) 0.1708 99.0(77.6–120.3) 0.3355
  Mixed with epithelioid tumor (N = 14) 59.5 (27.8–91.2)   76.8 (40.3–113.2)  
Pleomorphism Low (N = 61) 56.6 (51.6–106.1) 0.1914 123.3 (78.1–127.5) 0.2970
  High (N = 24) 25.1 (32.2–79.6)   76.9 (52.0–101.9)  
Mitotic count 5 of 50 HPF (N = 30) 182.3 (157.0–208.6) < 0.0001 182.4 (156.68–208.2) 0.0002
  > 5 of 50 HPF (N = 55) 43.7 (31.8–55.7)   73.8 (55.7–91.9)  
Cellularity Low (N = 53) 103.6 (71.8–135.5) < 0.0001 127.9 (98.5–157.4) 0.0001
  High (N = 32) 37.0 (20.1–53.8)   65.2 (42.3–88.1)  
Nuclear atypia Absence (N = 7) 71.8 (28.8–114.7) 0.4393 123.8 (37.5–210.2) 0.4685
  Presence (N = 78) 71.4 (51.3–91.6)   95.6 (72.5–18.6)  
Para-nuclear cytoplasmic Absence (N = 76) 69.6 (50.6–88.7) 0.4853 95.5 (74.9–116.1) 0.3995
vacuoles Presence (N = 9) 43.7 (30.1–57.3)   54.6 (42.7–66.5)  
Skeinoid fibers Absence (N = 72) 70.1 (50.6–89.7) 0.5636 95.3 (74.4–16.2) 0.4664
  Presence (N = 13) 50.4 (31.9–68.9)   63.8 (48.5–9.1)  
Inflammatory cell Absence (N = 65) 72.2 (52.1–92.3) 0.5754 98.0 (76.4–119.6) 0.7927
infiltration Presence (N = 20) 59.7 (33.6–85.9)   107.4 (54.6–103.2)  
Tumor border Infiltrating (N = 52) 88.6 (60.9–116.2) 0.2937 106.2 (77.9–137.0) 0.1884
  well-circumscribed (N = 33) 71.7 (53.2–90.1)   130.1 (82.7–129.7)  
Tumor necrosis Absence (N = 29) 131.1(82.3–179.9) 0.0061 148.3 (98.3–198.3) 0.0122
  Presence (N = 56) 53.8 (40.3–67.2)   82.2 (64.0–100.4)  
Mucosal invasion Absence (N = 54) 69.7 (46.0–93.5) 0.3993 99.8 (74.6–125.1) 0.9839
  Presence (N = 31) 69.2 (47.2–91.2)   83.3 (59.9–106.78)  
Ulceration Absence (N = 37) 78.9 (50.9–106.9) 0.4623 105.4 (76.3–134.4) 0.3830
  Presence (N = 48) 59.1 (43.6–74.6)   80.2 (62.8–97.6)  
Vascular proliferation Absence (N = 9) 130.4 (56.8–204.0) 0.0889 82.0 (154.3–209.8) 0.0192
  Presence (N = 76) 61.9 (49.4–4.5)   83.4 (68.6 – 98.3)  
Microscopic resection Negative (N = 81) 72.2 (52.71–91.8) 0.5059 97.9 (77.3–118.6) 0.6561
margins Positive (N = 4) 22.8 (17.1– 28.53)   30.6 (22.0–39.1)  
Lymphatic infiltration Absence (N = 83) 72.9 (53.3–92.6) 0.0768 99.8 (78.8–120.7) 0.0218
  Presence (N = 2) 19.8 (0.0–46.7)   29.1(14.6–43.6)  
  1. DFS = disease-free survival; OS = overall survival; GISTs = gastrointestinal stromal tumors