Table 3 Prognostic analysis of DFS and OS for GISTs of the small intestine in terms of histopathological features

Cell type

Spindle (N = 71)

75.1 (52.9–97.3)

0.1708

99.0(77.6–120.3)

0.3355

Mixed with epithelioid tumor (N = 14)

59.5 (27.8–91.2)

76.8 (40.3–113.2)

Pleomorphism

Low (N = 61)

56.6 (51.6–106.1)

0.1914

123.3 (78.1–127.5)

0.2970

High (N = 24)

25.1 (32.2–79.6)

76.9 (52.0–101.9)

Mitotic count

≦ 5 of 50 HPF (N = 30)

182.3 (157.0–208.6)

< 0.0001

182.4 (156.68–208.2)

0.0002

> 5 of 50 HPF (N = 55)

43.7 (31.8–55.7)

73.8 (55.7–91.9)

Cellularity

Low (N = 53)

103.6 (71.8–135.5)

< 0.0001

127.9 (98.5–157.4)

0.0001

High (N = 32)

37.0 (20.1–53.8)

65.2 (42.3–88.1)

Nuclear atypia

Absence (N = 7)

71.8 (28.8–114.7)

0.4393

123.8 (37.5–210.2)

0.4685

Presence (N = 78)

71.4 (51.3–91.6)

95.6 (72.5–18.6)

Para-nuclear cytoplasmic

Absence (N = 76)

69.6 (50.6–88.7)

0.4853

95.5 (74.9–116.1)

0.3995

vacuoles

Presence (N = 9)

43.7 (30.1–57.3)

54.6 (42.7–66.5)

Skeinoid fibers

Absence (N = 72)

70.1 (50.6–89.7)

0.5636

95.3 (74.4–16.2)

0.4664

Presence (N = 13)

50.4 (31.9–68.9)

63.8 (48.5–9.1)

Inflammatory cell

Absence (N = 65)

72.2 (52.1–92.3)

0.5754

98.0 (76.4–119.6)

0.7927

infiltration

Presence (N = 20)

59.7 (33.6–85.9)

107.4 (54.6–103.2)

Tumor border

Infiltrating (N = 52)

88.6 (60.9–116.2)

0.2937

106.2 (77.9–137.0)

0.1884

well-circumscribed (N = 33)

71.7 (53.2–90.1)

130.1 (82.7–129.7)

Tumor necrosis

Absence (N = 29)

131.1(82.3–179.9)

0.0061

148.3 (98.3–198.3)

0.0122

Presence (N = 56)

53.8 (40.3–67.2)

82.2 (64.0–100.4)

Mucosal invasion

Absence (N = 54)

69.7 (46.0–93.5)

0.3993

99.8 (74.6–125.1)

0.9839

Presence (N = 31)

69.2 (47.2–91.2)

83.3 (59.9–106.78)

Ulceration

Absence (N = 37)

78.9 (50.9–106.9)

0.4623

105.4 (76.3–134.4)

0.3830

Presence (N = 48)

59.1 (43.6–74.6)

80.2 (62.8–97.6)

Vascular proliferation

Absence (N = 9)

130.4 (56.8–204.0)

0.0889

82.0 (154.3–209.8)

0.0192

Presence (N = 76)

61.9 (49.4–4.5)

83.4 (68.6 – 98.3)

Microscopic resection

Negative (N = 81)

72.2 (52.71–91.8)

0.5059

97.9 (77.3–118.6)

0.6561

margins

Positive (N = 4)

22.8 (17.1– 28.53)

30.6 (22.0–39.1)

Lymphatic infiltration

Absence (N = 83)

72.9 (53.3–92.6)

0.0768

99.8 (78.8–120.7)

0.0218

Presence (N = 2)

19.8 (0.0–46.7)

29.1(14.6–43.6)