Peripheral blood mononuclear cells (PBMCs) were got from all subjects and cultured in the presence of specific antigens. Supernatants were collected on day 4 and subjected to the assessment of IL-4 (A) and IFN-γ (B) with ELISA. Blank: no special treatment. Ag: treated with specific antigens. SEB: treated with SEB; SEB+Ag: treated with the combination of SEB and Ag. Data are presented as mean ± SD. *, p < 0.05, compared with blank group; #, p < 0.05, compared with the groups treated with Ag alone or with SEB alone.