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Figure 5 | BMC Gastroenterology

Figure 5

From: Integrative roles of transforming growth factor-α in the cytoprotection mechanisms of gastric mucosal injury

Figure 5

COX-2 and NFκB expression in the gastric mucosa. (a) Immunostaining of COX-2. COX-2 was intensively induced after the injury at the lower glandular region of the WT mucosa, whereas it was constitutively expressed in the same region of the TG mucosa even before the injury. Ethanol-injured mucosa was stained 6 h after the ethanol administration. Scale: 100 μm. (b) Immunoblotting of COX-2 and COX-1. The blots were measured 0, 3, and 6 h after the injury. Actin filaments were used as a control. Note that COX-2 was intensively expressed before the injury in the TG mucosa. (c) Measurement of prostaglandin E2. Prostaglandin E2 levels were measured before the ethanol treatment in the WT and TG mucosae. n = 5, p = 0.013. (d) Immunostaining of NFκB. NFκB was intensively induced after the injury at the same lower glandular region of the WT mucosa as was COX-2. In contrast, NFκB was constitutively expressed in the same region of the TG mucosa even before the injury. Scale: 100 μm.

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