Factors associated with disease evolution in Greek patients with inflammatory bowel disease

BMC Gastroenterology

Table 2 Univariate analysis of risk of change of disease behaviour in patients with B1 disease at diagnosis

	Patients without change of disease behaviour (N = 42)	Patients with change of disease behaviour (N = 38)	P^§
Males	26 (61.9%)	20 (52.6%)	0.180^†
Months to diagnosis	49.2 ± 43.5	39.6 ± 41.2	NS
A1	29 (69%)	31 (81.5%)	0.147^†
Positive family history	4 (9.5%)	6 (15.7%)	NS
Location of disease
L1	3 (11.9%)	9 (23.6%)	0.005
L2	20 (47.6%)	5 (13.1%)	0.006
L3	15 (35.7 %)	19 (50%)	NS
L4	4 (9.5%)	5 (13.1%)	NS
Current smoking	13 (30.9%)	28 (73.6%)	0.001
Continuous course	4 (9.5%)	13 (34.2%)	0.016
Immunosuppressives	11 (26.1%)	9 (23.6%)*	NS
Surgery at diagnosis^‡	1 (2.3%)	1 (2.6%)	NS

Values are given as mean ± SD or number of patients; Values in parentheses are percentages; N, number; A1, age at diagnosis ≤ 40 years; L1, ileal location; L2, colonic location; L3, ileo-colonic location; L4, disease of the upper gastro-intestinal tract; *Data collected until change of disease behavior; ^§P values from survival analysis using log-rank test; ^‡Surgery at diagnosis refers to bowel resections; ^†Variables having a p value between 0.51 and 0.2, although insignificant, were included in the regression analysis to avoid confounding effects;

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