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Table 1 Characteristics of patients, HBV genotypes and mutant

From: Genetic variability in the precore and core promoter regions of hepatitis B virus strains in Karachi

 

HBeAg Negative Patients (n = 71)

HBeAg Positive Patients (n = 38)

pvalue

Sex (M/F)

57/14

28/10

0.428

Age (Yrs)

33.8 ± 12.6

31.4 ± 11.5

0.464

Serum bilirubin (mg/dl)

1.4 ± 2.9

0.9 ± 0.8

0.247

ALT (U/L)

61 ± 79

93 ± 137

0.236

Alkaline phosphatase (U/L)

169 ± 124

195 ± 169

0.450

Serum Albumin (g/dl)

3.5 ± 1.0

3.6 ± 1.1

0.714

Platelet count (106/μL)

179 ± 76

171 ± 80

0.751

Clinical cirrhosis

16

06

0.717

Genotype D*

71

38

1.000

Coinfection with genotype

00

02

 

Mutations

   

Precore G1896A

22

07

0.157

BCP A1762T

11

00

0.010√

BCP G1764A

27

06

0.016√

Absent wild PC band

22

05

0.040√

Absent wild BCP band

34

07

0.002√

Overall mutants**

44

09

0.000√

More than one mutations

26

06

0.023√

  1. *Genotype D present in all the patients. **More than one mutations in many patients. PC: precore, BCP: basal core promoter. √Significant p values
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BMC Gastroenterology

ISSN: 1471-230X

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