Figure 6

Expression of proinflammatory cytokines in IL-12KO mice. RRV infection in the first day of life leads to an increased hepatic mRNA expression of IFNγ (A), TNFα (B), IFNα (C) and IFNβ (D) in IL-12KO mice above levels of saline-injected IL-12KO mice and WT mice injected with RRV. Also shown are the levels of expression. Levels of expression are shown as a ratio to GAPDH; *P < 0.05 for IL-12KO mice injected with RRV vs saline; #P < 0.05 for IL-12KO mice are compared to WT, both after RRV infection; N = 4–6 mice per group at each time point.