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Figure 3 | BMC Gastroenterology

Figure 3

From: Decreased expression of cytochrome P450 protein in non-malignant colonic tissue of patients with colonic adenoma

Figure 3

Diminished protein levels of CYP2C8, CYP3A4, and CYP3A5 in normal colon mucosa of patients with colonic adenoma. (A) Representative Western blots of CYP2C8, CYP2E1, CYP3A4, and CYP3A5 in normal colon mucosa from patients with colonic adenomas and disease-free controls. (B) Representative Western blot of β-actin protein in normal mucosa of patients with colonic adenoma and disease-free controls. (C) Quantitative analysis of blots. CYP2E1, CYP3A4, and CYP3A5 protein levels were determined in 25 patients with adenoma und 27 disease-free controls. CYP2C8 protein levels were determined in 19 cases and 12 disease-free controls. Data are means ± SEM, ap < 0.05 compared to disease-free controls.

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