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Table 2 Comparisons of laboratory data and BMD measurements of children with chronic hepatitis B treated with IFN-alpha alone or combination with lamivudine and healthy controls.

From: Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?

Variables Patients (n = 54) Control (n = 50) P
TNF-α 25.54 ± 8.30 15.47 ± 6.77 NS
IL-1β 7.32 ± 12.13 5.48 ± 6.14 NS
IL-2r 1403.07 ± 455.67 1120.48 ± 492.37 0.002
IL-6 25.21 ± 39.27 5.98 ± 6.49 0.001
IL-8 18.46 ± 14.77 12.55 ± 7.36 0.013
PTH 41.51 ± 28.80 33.08 ± 18.22 0.029
s-CTX 1.92 ± 0.76 1.61 ± 0.52 0.021
Osteocalcin 64.67 ± 30.63 75.81 ± 31.10 NS
Serum calcium 9.57 ± 1.83 9.49 ± 1.52 NS
ALP 221.27 ± 67.27 219.66 ± 78.74 NS
ALT 62.14 ± 88.31 27.01 ± 42.41 0.009
AST 58.41 ± 65.57 31.72 ± 29.69 0.007
L2–4 BMD 0.62 ± 0.13 0.59 ± 0.12 NS
Femur neck BMD 0.80 ± 0.16 0.72 ± 0.15 0.012
Trochanter BMD 0.68 ± 0.14 0.62 ± 0.14 0.046