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Table 1 Comparisons of clinical features in patients with chronic hepatitis B treated with IFN alone or IFN plus lamivudine

From: Bone mineral density and cytokine levels during interferon therapy in children with chronic hepatitis B: does interferon therapy prevent from osteoporosis?

Variables

IFN-alpha (n = 19)

IFN plus Lamivudine (n = 35)

P

TNF-α

24.48 ± 8.46

26.60 ± 7.43

NS

IL-1β

7.56 ± 10.86

7.08 ± 12.47

NS

IL-2r

1472.42480.47

1333.72 ± 472.51

NS

IL-6

24.85 ± 31.46

25.57 ± 29.43

NS

IL-8

18.19 ± 13.88

18.73 ± 14.27

NS

PTH

42.03 ± 29.41

40.99 ± 26.92

NS

s-CTX

1.88 ± 0.68

1.96 ± 0.75

NS

Osteocalcin

65.49 ± 34.45

63.85 ± 32.67

NS

Serum calcium

9.28 ± 1.76

9.86 ± 1.69

NS

ALP

249.45 ± 71.34

193.09 ± 72.88

NS

ALT

62.83 ± 76.39

61.45 ± 81.54

NS

AST

59.16 ± 61.48

57.66 ± 59.82

NS

L2–4 BMD

0.63 ± 0.09

0.61 ± 0.14

NS

Femur neck BMD

0.78 ± 0.12

0.82 ± 0.17

NS

Trochanter BMD

0.67 ± 0.16

0.69 ± 0.12

NS