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Table 3 Studies showing p16 alterations in tissue specimen of primary pancreatic ductal adenocarcinomas.

From: Alterations of tumor suppressor gene p16 INK4ain pancreatic ductal carcinoma

Study Number of cases p16 gene alterations
   Homozygous deletion Mutation Methylation
Huang et al (1996) 30 10% 17% NE
Zhonghua et al (2000) 35 35% 20% NE
Moore et al (2002) 34 NE 23% 15%
Gerdes et al (2002) 40 ND 22.5% 27.5%
Ohtsubo et al (2003) 60 ND 15% 3.3%
Present study 25 12% 16% 52%
  1. NE: Not Examined; ND: Not Detected