Figure 9

Effect of endotoxin on gastric emptying. A. Gastric emptying curve generated 1 hour after endotoxin (0.1 mg/kg, solid line) or carrier (dashed line) injection. A methylcellulose/phenol red dye meal was administered to different groups of mice by intragastric gavage. The amount of dye remaining in the stomach after a 1, 15, 30 or 45 minute transit period was measured. The percent of dye emptied was calculated relative to the total amount of dye gavaged. Each data point represents measurements from 3 – 7 mice. B. The recovery of gastric function was monitored by measuring the 30 minute emptying at various times after administration of endotoxin (0.1 mg/kg, solid line) or carrier (dashed line). N = 3–12 mice per group. C. Correlation plot comparing the recovery of food intake and gastric emptying. Data points represent percentages of the corresponding control. The data point numbers represent the first, second and third scotophase for food intake measurements (ordinate) or the gastric emptying measurement made preceding each scotophase (abscissa). Values are mean ± SEM.