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Table 3 Features of HFE C282Y homozygotes. Cases 1–3 were from Norwich, cases 1 and 2 were included in our previous study [11].

From: Hepatocellular carcinoma and the penetrance of HFEC282Y mutations: a cross sectional study

 

Histology (and histological staging of fibrosis)

Grade of Siderosis (liver iron)

Venesectiona

Age#

Sex

1

HCC (inadequate for staging)

NA*

No

66

M

2

HCC, cirrhosis (inadequate for staging)

Grade 1

No

70

M

3

HCC (inadequate for staging)

Grade 3/4

Yes

64

M

4

HCC, fibrosis (stage 4)

Grade 2/3

Yes

64

M

5

HCC, cirrhosis (stage 6)

Grade 4

No

73

M

6

HCC, fibrosis (stage 4)

Grade 1

Yes

64

M

7

HCC, cirrhosis (stage 6)

Grade 4

Not known

63

M

8

HCC, cirrhosis (stage 6)

Grade 2/3

Yes

62

M

  1. a Information about previous venesection treatment obtained from histology request forms and reports.
  2. # Age at biopsy.
  3. * Not applicable; only tumour was present in the needle biopsy sample.
  4. HCC, hepatocellular carcinoma.