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Table 2 Amino acid measurements (μMol/l)

From: The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis

  

PBC (n = 45)

PSC (n = 27)

HCV (n = 22)

controls

Aromatic amino acids

Tyrosine (mean ± SD)

76 ± 26

p = 0.0002

69 ± 24

p = 0.07

73 ± 25

p = 0.01

62 ± 14.4

 

Phenylalanine (mean ± SD)

65 ± 15

p < 0.0001

59 ± 11

p = 0.11

54 ± 8

p = 0.26

56 ± 6.9

 

Tryptophan (mean ± SD)

39 ± 8

p < 0.0001

43 ± 11

p = 0.085

40 ± 8

p = 0.0003

46 ± 6.1

Branched chain amino acids

Valine (mean ± SD)

211 ± 47

p = 0.002

208 ± 42

p = 0.002

232 ± 45

p = 0.56

238 ± 41.7

 

Isoleucine (mean ± SD)

55 ± 16

p < 0.0001

53 ± 13

p < 0.0001

67 ± 19

p = 0.51

70 ± 18.8

 

Leucine (mean ± SD)

107 ± 30

p < 0.0001

101 ± 25

p < 0.0001

119 ± 28

p = 0.053

132 ± 27.1

Calculated ratio's

Tryptophan-ratio (mean ± SD)

7.7 ± 1.5

p = 0.02

8.9 ± 1.8

p = 0.051

7.5 ± 1.0

p = 0.004

8.3 ± 1.14

 

Tyrosine-ratio (mean ± SD)

16.3 ± 6.5

p < 0.0001

15.1 ± 5.0

p < 0.0001

14.0 ± 3.5

p < 0.0001

11.4 ± 2.17