Table 2 Amino acid measurements (μMol/l)
| PBC (n = 45) | PSC (n = 27) | HCV (n = 22) | controls | ||
|---|---|---|---|---|---|
| Aromatic amino acids | Tyrosine (mean ± SD) |
76 ± 26 p = 0.0002 |
69 ± 24 p = 0.07 |
73 ± 25 p = 0.01 | 62 ± 14.4 |
| Phenylalanine (mean ± SD) |
65 ± 15 p < 0.0001 |
59 ± 11 p = 0.11 |
54 ± 8 p = 0.26 | 56 ± 6.9 | |
| Tryptophan (mean ± SD) |
39 ± 8 p < 0.0001 |
43 ± 11 p = 0.085 |
40 ± 8 p = 0.0003 | 46 ± 6.1 | |
| Branched chain amino acids | Valine (mean ± SD) |
211 ± 47 p = 0.002 |
208 ± 42 p = 0.002 |
232 ± 45 p = 0.56 | 238 ± 41.7 |
| Isoleucine (mean ± SD) |
55 ± 16 p < 0.0001 |
53 ± 13 p < 0.0001 |
67 ± 19 p = 0.51 | 70 ± 18.8 | |
| Leucine (mean ± SD) |
107 ± 30 p < 0.0001 |
101 ± 25 p < 0.0001 |
119 ± 28 p = 0.053 | 132 ± 27.1 | |
| Calculated ratio's | Tryptophan-ratio (mean ± SD) |
7.7 ± 1.5 p = 0.02 |
8.9 ± 1.8 p = 0.051 |
7.5 ± 1.0 p = 0.004 | 8.3 ± 1.14 |
| Tyrosine-ratio (mean ± SD) |
16.3 ± 6.5 p < 0.0001 |
15.1 ± 5.0 p < 0.0001 |
14.0 ± 3.5 p < 0.0001 | 11.4 ± 2.17 |