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Table 3 Uunivariate analysis of the relationship between survival and the tested markers

From: Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients

PredictiveVariables Median Survival HR CI P
Ki-67
   <11.5 36    
   ≥11.5 32 1.826 0.636 – 5.243 0.26
Cyclin D1
   <6.1 35    
   ≥6.1 18 7.246 1.007 – 45.150 0.03*
Histone H3
   <8.2 35    
   ≥8.2 29 4.639 0.854 – 25.196 0.07
Cyclin A
   <10.5 35    
   ≥10.5 15 7.820 1.017 – 60.122 0.02*
Histological grade
   Low 38    
   High 10 7.331 2.696 – 19.940 0.0001*
Lymph node
   Negative 38    
   Positive 15 6.826 1.973 – 23.621 0.002*
Stage
   I, II, III 38    
   IV 12 6.378 1.842 – 22.083 0.001*
Tumor size (cm)
   <5.0 35    
   ≥5.0 13 4.835 1.386 – 16.868 0.01*
Depth of invasion
   T1, T2 36    
   T3, T4 20 7.759 1.024 – 58.789 0.04*
Age (years)
   <50 38    
   ≥50 28 2.802 0.988 – 7.943 0.0526
Sex
   Male 38    
   Female 36 0.696 00.274 – 1.766 0.4449
  1. * p. value < 0.05 (significant)
  2. HR: Hazard Ratio
  3. CI: 95% confidence Interval