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Table 2 The relation between cyclin D1 overexpression vs cyclin D1 amplification and clinicopathological prognostic markers.

From: Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients

Variables

No. of cases

Cyclin DI overexpression

Cyclin D1 Amplification

Tumor size (cm)

   <5.0

33

5.3 ± 3.8*

13/33

   ≥5.0

27

22.8 ± 7.2 p <0.05

9/27 p <0.236

Histology

   GI

15

6.6 ± 4.0

7/15

   GII

21

8.9 ± 3.6

8/21

   GIII

24

22.0 ± 8.1 p <0.001

7/24 p <0.075

Lymph node

   Negative

33

5.4 ± 5.3*

6/33 (18.2%)

   Positive

27

20.6 ± 6.9 p <0.05

16/27 (59.3%) p <0.008

Depth of invasion

   m, sm

17

3.1 ± 3.1*

4/17 (23.5%)

   beyond sm

43

12.4 ± 6.5 p <0.05

26/43 (60.5%) p <0.001

Stage

   early

45

5.5 ± 10.1

12/45 (26.7%)

   late

15

11.3 ± 9.6 P = 0.175

10/15 (66.7%) p <0.002