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Table 2 The relation between cyclin D1 overexpression vs cyclin D1 amplification and clinicopathological prognostic markers.

From: Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients

Variables No. of cases Cyclin DI overexpression Cyclin D1 Amplification
Tumor size (cm)
   <5.0 33 5.3 ± 3.8* 13/33
   ≥5.0 27 22.8 ± 7.2 p <0.05 9/27 p <0.236
Histology
   GI 15 6.6 ± 4.0 7/15
   GII 21 8.9 ± 3.6 8/21
   GIII 24 22.0 ± 8.1 p <0.001 7/24 p <0.075
Lymph node
   Negative 33 5.4 ± 5.3* 6/33 (18.2%)
   Positive 27 20.6 ± 6.9 p <0.05 16/27 (59.3%) p <0.008
Depth of invasion
   m, sm 17 3.1 ± 3.1* 4/17 (23.5%)
   beyond sm 43 12.4 ± 6.5 p <0.05 26/43 (60.5%) p <0.001
Stage
   early 45 5.5 ± 10.1 12/45 (26.7%)
   late 15 11.3 ± 9.6 P = 0.175 10/15 (66.7%) p <0.002