From: Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
Variables | No. of cases | Cyclin DI overexpression | Cyclin D1 Amplification |
---|---|---|---|
Tumor size (cm) | |||
   <5.0 | 33 | 5.3 ± 3.8* | 13/33 |
   ≥5.0 | 27 | 22.8 ± 7.2 p <0.05 | 9/27 p <0.236 |
Histology | |||
   GI | 15 | 6.6 ± 4.0 | 7/15 |
   GII | 21 | 8.9 ± 3.6 | 8/21 |
   GIII | 24 | 22.0 ± 8.1 p <0.001 | 7/24 p <0.075 |
Lymph node | |||
   Negative | 33 | 5.4 ± 5.3* | 6/33 (18.2%) |
   Positive | 27 | 20.6 ± 6.9 p <0.05 | 16/27 (59.3%) p <0.008 |
Depth of invasion | |||
   m, sm | 17 | 3.1 ± 3.1* | 4/17 (23.5%) |
   beyond sm | 43 | 12.4 ± 6.5 p <0.05 | 26/43 (60.5%) p <0.001 |
Stage | |||
   early | 45 | 5.5 ± 10.1 | 12/45 (26.7%) |
   late | 15 | 11.3 ± 9.6 P = 0.175 | 10/15 (66.7%) p <0.002 |