Skip to main content

Table 1 Clinicopathological features of patients in relation to the staining index (SI) of Ki-67, cyclin D1, cyclin A, histone H3

From: Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients

   SI (mean + SD)
Variables No. of cases Ki-67 Cyclin DI Cyclin A Histone H3
Sex
   Male 36 18.0 ± 6.4 6.7 ± 4.3 12.7 ± 5.7 10.7 ± 5.3
   Female 24 20.1 ± 5.8 8.8 ± 8.4 10.0 ± 6.0 10.7 ± 5.4
Age (years)
   ≥50 41 11.7 ± 6.0* 5.6 ± 5.2 10.0 ± 5.3 6.0 ± 5.0*
   <50 19 23.8 ± 5.6 7.7 ± 6.8 13.6 ± 5.7 22.0 ± 5.2
Tumor size (cm)
   <5.0 33 12.2 ± 6.3* 5.3 ± 3.8* 11.5 ± 6.1* 10.3 ± 4.9*
   ≥5.0 27 30.1 ± 6.2 22.8 ± 7.2 28.6 ± 5.6 24.0 ± 5.6
Histology
   Normal 20 3.5 ± 2.0* 0.6 ± 0.2* 2.3 ± 1.1* 2.2 ± 0.9
   Carcinoma 60 30.3 ± 6.2 24.9 ± 6.3 27.2 ± 5.8 10.7 ± 5.3
   GI 15 11.7 ± 6.2 6.6 ± 4.0 10.0 ± 5.4 11.4 ± 4.9
   GII 21 11.8 ± 5.6 8.9 ± 3.6 12.3 ± 6.5 7.8 ± 5.4
   GIII 24 30.0 ± 4.3 22.0 ± 8.1 27.0 ± 4.9 11.5 ± 5.4
Lymph node
   Negative 33 19.5 ± 7.0 5.4 ± 5.3* 11.9 ± 6.5 12.3 ± 5.5
   Positive 27 21.3 ± 4.9 20.6 ± 6.9 12.5 ± 5.0 14.2 ± 5.0
Depth of invasion
   m, sm 17 20.7 ± 6.7 3.1 ± 3.1* 11.9 ± 7.2 10.4 ± 5.1
   beyond sm 43 21.9 ± 6.2 12.4 ± 6.5 12.2 ± 5.6 10.7 ± 5.4
Stage
   I 6 20.6 ± 6.7 5.7 ± 6.9 24.2 ± 6.9 11.1 ± 5.3
   II 27 20.8 ± 6.9 5.3 ± 4.3 24.6 ± 6.0 10.4 ± 5.7
   III 12 22.0 ± 5.4 7.7 ± 6.0 27.1 ± 5.2 10.4 ± 4.9
   IV 15 24.7 ± 6.1 11.3 ± 9.6 27.5 ± 5.5 12.3 ± 6.2
  1. * p. value < 0.05 (significant)