Table 1 Clinicopathological features of patients in relation to the staining index (SI) of Ki-67, cyclin D1, cyclin A, histone H3

Sex

   Male

18.0 ± 6.4

6.7 ± 4.3

12.7 ± 5.7

10.7 ± 5.3

   Female

20.1 ± 5.8

8.8 ± 8.4

10.0 ± 6.0

10.7 ± 5.4

Age (years)

   ≥50

11.7 ± 6.0*

5.6 ± 5.2

10.0 ± 5.3

6.0 ± 5.0*

   <50

23.8 ± 5.6

7.7 ± 6.8

13.6 ± 5.7

22.0 ± 5.2

Tumor size (cm)

   <5.0

12.2 ± 6.3*

5.3 ± 3.8*

11.5 ± 6.1*

10.3 ± 4.9*

   ≥5.0

30.1 ± 6.2

22.8 ± 7.2

28.6 ± 5.6

24.0 ± 5.6

Histology

   Normal

3.5 ± 2.0*

0.6 ± 0.2*

2.3 ± 1.1*

2.2 ± 0.9

   Carcinoma

30.3 ± 6.2

24.9 ± 6.3

27.2 ± 5.8

10.7 ± 5.3

   GI

11.7 ± 6.2

6.6 ± 4.0

10.0 ± 5.4

11.4 ± 4.9

   GII

11.8 ± 5.6

8.9 ± 3.6

12.3 ± 6.5

7.8 ± 5.4

   GIII

30.0 ± 4.3

22.0 ± 8.1

27.0 ± 4.9

11.5 ± 5.4

Lymph node

   Negative

19.5 ± 7.0

5.4 ± 5.3*

11.9 ± 6.5

12.3 ± 5.5

   Positive

21.3 ± 4.9

20.6 ± 6.9

12.5 ± 5.0

14.2 ± 5.0

Depth of invasion

   m, sm

20.7 ± 6.7

3.1 ± 3.1*

11.9 ± 7.2

10.4 ± 5.1

   beyond sm

21.9 ± 6.2

12.4 ± 6.5

12.2 ± 5.6

10.7 ± 5.4

Stage

   I

20.6 ± 6.7

5.7 ± 6.9

24.2 ± 6.9

11.1 ± 5.3

   II

20.8 ± 6.9

5.3 ± 4.3

24.6 ± 6.0

10.4 ± 5.7

   III

22.0 ± 5.4

7.7 ± 6.0

27.1 ± 5.2

10.4 ± 4.9

   IV

24.7 ± 6.1

11.3 ± 9.6

27.5 ± 5.5

12.3 ± 6.2