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Table 2 Kinetic constants (Maximal velocity – Vmax- and the affinity transporter constant – Kt-) for galactose and amino acid uptake by BBMVs in the three experimental groups:

From: Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I

Nutrient Kinetic constants Control group (CO, n = 10) Untreated cirrhotic rats (CI, n = 10) Cirrhotic rats treated with IGF-I (CI+IGF, n = 10)
D-galactose Vmax 3470 ± 30 2460 ± 24*** 3008 ± 45*
  Kt 0.71 ± 0.01 1.03 ± 0.02** 0.78 ± 0.02
L-leucine Vmax 305 ± 19 210 ± 15** 283 ± 18
  Kt 1.6 ± 0.1 2.0 ± 0.2** 1.1 ± 0.1
L-proline Vmax 165 ± 32 92 ± 7 159 ± 28
  Kt 1.9 ± 0.2 3.3 ± 0.2*** 2.1 ± 0.1
L-glutamic acid Vmax 828 ± 23 545 ± 13*** 789 ± 18
  Kt 0.6 ± 0.0 1.1 ± 0.0** 0.8 ± 0.0
L-cysteine Vmax 195 ± 26 105 ± 11*** 182 ± 19
  Kt 1.9 ± 0.1 2.3 ± 0.2** 1.9 ± 0.1
  1. Values are mean ± SEM, n = pool of BBMVs from 10 animals from each group. Vmax expressed as pmol of substrate/ mg protein × 3 seconds and Kt as mmol/l. *p < 0.05, **p < 0.01, ***p < 0.001 CO vs other groups.