S. No | Findings | A-GVHD cases Group A n= 44 | Negative controles (B+C)* n= 48 | Sp | Sn | PPV | NPV | |||
---|---|---|---|---|---|---|---|---|---|---|
 |  |  | TP | FN | TN | FP |  |  |  |  |
1. | Apoptosis | (K2) Apoptosis in crypt lining | 40 | 4 | 42 | 6 | 87 | 91 | 93 | 91 |
 |  | (K4) Pericryptal apoptosis in LP, adjacent to the crypts | 31 | 13 | 41 | 7 | 85 | 70 | 84 | 93 |
2. | Crypt abnormalities | (D1) Crypt size variation | 43 | 1 | 37 | 11 | 77 | 98 | 100 | 97 |
 |  | (E) Crypt dilatation | 32 | 12 | 47 | 1 | 98 | 73 | 97 | 80 |
 |  | (D2) Irregular distribution of crypts | 28 | 16 | 47 | 1 | 98 | 64 | 97 | 75 |
3. | Reactive changes a. In lamina propria | (R) Increased LP microvascular network | 27 | 17 | 48 | 0 | 100 | 61 | 100 | 74 |
 |  | (T1)Focal fibrosis in LP | 21 | 23 | 46 | 2 | 96 | 48 | 100 | 67 |
 |  | (A) Reduced mucosal thickness | 21 | 23 | 48 | 0 | 100 | 48 | 100 | 68 |
 |  | (Q) Muciphages in LP | 18 | 26 | 42 | 6 | 87 | 41 | 100 | 62 |
 | b. In surface epithelium | (C) Reactive changes in SE | 18 | 26 | 48 | 0 | 100 | 41 | 100 | 65 |