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Table 4 Summary of diagnostically significant morphological features associated with intestinal A-GVHD¶.

From: Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients

S. No

Findings

A-GVHD cases Group A n= 44

Negative controles (B+C)* n= 48

Sp

Sn

PPV

NPV

   

TP

FN

TN

FP

    

1.

Apoptosis

(K2) Apoptosis in crypt lining

40

4

42

6

87

91

93

91

  

(K4) Pericryptal apoptosis in LP, adjacent to the crypts

31

13

41

7

85

70

84

93

2.

Crypt abnormalities

(D1) Crypt size variation

43

1

37

11

77

98

100

97

  

(E) Crypt dilatation

32

12

47

1

98

73

97

80

  

(D2) Irregular distribution of crypts

28

16

47

1

98

64

97

75

3.

Reactive changes a. In lamina propria

(R) Increased LP microvascular network

27

17

48

0

100

61

100

74

  

(T1)Focal fibrosis in LP

21

23

46

2

96

48

100

67

  

(A) Reduced mucosal thickness

21

23

48

0

100

48

100

68

  

(Q) Muciphages in LP

18

26

42

6

87

41

100

62

 

b. In surface epithelium

(C) Reactive changes in SE

18

26

48

0

100

41

100

65

  1. ¶Morphological features demonstrating statistically significant association with A-GVHD (selected from Table 2). *Addition of Group B (27) and Group C (21). Due to the lack of ideal but practical negative control (as discussed in the text), sensitivities and specificities calculated in this study are based on the practical negative controls in group B and C. TP, true positive; FN, false negative; TN, true negative; FP, false positive, LP, lamina propria, SE, surface epithelium. Sp, Specificity; Sn, Sensitivity; PPV, Positive predictive value; NPV, Negative predictive value.