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Table 4 Summary of diagnostically significant morphological features associated with intestinal A-GVHD.

From: Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients

S. No Findings A-GVHD cases Group A n= 44 Negative controles (B+C)* n= 48 Sp Sn PPV NPV
    TP FN TN FP     
1. Apoptosis (K2) Apoptosis in crypt lining 40 4 42 6 87 91 93 91
   (K4) Pericryptal apoptosis in LP, adjacent to the crypts 31 13 41 7 85 70 84 93
2. Crypt abnormalities (D1) Crypt size variation 43 1 37 11 77 98 100 97
   (E) Crypt dilatation 32 12 47 1 98 73 97 80
   (D2) Irregular distribution of crypts 28 16 47 1 98 64 97 75
3. Reactive changes a. In lamina propria (R) Increased LP microvascular network 27 17 48 0 100 61 100 74
   (T1)Focal fibrosis in LP 21 23 46 2 96 48 100 67
   (A) Reduced mucosal thickness 21 23 48 0 100 48 100 68
   (Q) Muciphages in LP 18 26 42 6 87 41 100 62
  b. In surface epithelium (C) Reactive changes in SE 18 26 48 0 100 41 100 65
  1. Morphological features demonstrating statistically significant association with A-GVHD (selected from Table 2). *Addition of Group B (27) and Group C (21). Due to the lack of ideal but practical negative control (as discussed in the text), sensitivities and specificities calculated in this study are based on the practical negative controls in group B and C. TP, true positive; FN, false negative; TN, true negative; FP, false positive, LP, lamina propria, SE, surface epithelium. Sp, Specificity; Sn, Sensitivity; PPV, Positive predictive value; NPV, Negative predictive value.