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Table 2 Comparison of histological features in group A with A-GVHD and negative controls in group B & C.

From: Colon biopsies for evaluation of acute graft-versus-host disease (A-GVHD) in allogeneic bone marrow transplant patients

    Frequency of the histological features in %
Histological features evaluated   Negative control
    A-GVHD Grp A (n= 44) Grp B (n= 27) Grp C (n= 21)
A Reduced mucosal thickness 47.73% 0.00%* 0.00%*
B Mucosal ulceration 27.27% 0.00%* 0.00%*
C Reactive changes in superficial epithelium 41.86% 0.00%* 0.00%*
D1   Size variation 97.73% 29.63%* 14.28%*
D2 Crypt abnormalities Irregular distribution 63.64% 3.70%* 0.00%*
D3   Crypt dropout 30.23% 0.00%* 0.00%*
E Crypt dilatation 72.73% 3.70%* 0.00%*
F Cryptitis and crypt abscess 2.27% 0.00% 4.76%
G Increased intraepithelial lymphocytes in superficial epithelium 6.98% 0.00% 0.00%
H Increased intraepithelial lymphocytes in crypts 6.98% 0.00% 0.00%
I Intraepithelial neutrophils in superficial epithelium 9.30% 0.00% 0.00%
J Intraepithelial neutrophils in crypts 6.82% 0.00% 0.00%
K1   Intraepithelial in SE 76.74% 77.78% 57.4%
K2   Intracryptal ("popcorn") 90.91% 11.11%* 14.28%*
K3 Distribution of apoptosis Lamina propria, near SE 79.55% 70.37% 85.7%
K4   Pericryptal 70.45% 22.22%* 4.76%*
L0   None 59.09% 74.07% 57.14%
L1 Neutrophils in lamina propria Marked increase 4.55% 18.52% 00.00%
L2   Mild increase 36.36% 11.11% 42.85%
M0 Eosinophils in lamina propria Few to none 100% 96.30% 100.00%
M1   many 0.00% 3.70% 0.00%
N Focal periglandular infiltrate 6.98% 0.00% 0.00%
O1 Edema in lamina propria Focal 86.36% 88.88% 28.57%
O2   Diffuse 4.55% 0.00% 0.00%
P Muciphages in lamina propria 43.18% 0.00%* 4.76%*
Q Increased microvessel network in lamina propria   61.36% 0.00%* 0.00%*
R Clusters of enterochromaffin cells 0.00% 0.00% 0.00%
S1 Fibrosis in lamina propria Focal 47.73% 0.00%* 0.00%*
S2   Diffuse 2.27% 0.00% 0.00%
  1. n, total number of cases in a group; SE, surface epithelium. * Statistically significant difference with p values less than 0.002 with Fisher's exact test when A was compared with B and C individually.