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Figure 3 | BMC Gastroenterology

Figure 3

From: Transfection of IL-10 expression vectors into endothelial cultures attenuates α4β7-dependent lymphocyte adhesion mediated by MAdCAM-1

Figure 3

IL-10 gene transfer blocked TNF-α induced lymphocyte adhesion on SVEC. TNF-α stimulation (1 ng/ml, 24 h) significantly increased the adhesion of TK-1 lymphocytes to SVEC monolayers. IL-10 gene transfer significantly reduced TK-1 adhesion in response to TNF-α stimulation at 24 h. IL-10 gene transfer did not modify the basal level of lymphocyte adhesion to the endothelium without TNF-α treatment (n = 7). (* p < 0.05 from TNF-α, # p < 0.05 from control). One-way ANOVA with Fisher's PLSD test.

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