Effects of U0126 on HepG2 cell morphology. HepG2 cells were grown and treated with either 0.1% DMSO or 3 doses of U0126 in PSF medium for 48 h as described under Experimental Procedures. Bright field views of cells treated with 0.1% DMSO (A) or 2 (B), 4 (C), and 6 (D) μM of U0126 for 48 hours. Representative samples are shown. Original magnification, ×200.