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Table 1 The ulcerogenic and intestinal permeability (51Cr-EDTA excretion) effect of DMSO (Control), indomethacin, DAHP pretreated indomethacin and nabumetone gavaged rat small intestine.

From: 2, 4-Diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum

Group Treatment Pointed ulcers Longitudinal ulcers % Excretion of 51Cr-EDTA in Urine
1 Control(DMSO) 0 0 2.3 ± 1.2
2 Indomethacin 55 ± 10 15 ± 9 * 10.5 ± 2.5
3 DAHP pretreated indomethacin 0 0 * 11.5 ± 0.8
4 Nabumetone 0 0 2.7 ± 1.5
  1. * P < 0.01