Table 1 The ulcerogenic and intestinal permeability (51Cr-EDTA excretion) effect of DMSO (Control), indomethacin, DAHP pretreated indomethacin and nabumetone gavaged rat small intestine.
Group | Treatment | Pointed ulcers | Longitudinal ulcers | % Excretion of 51Cr-EDTA in Urine |
|---|---|---|---|---|
1 | Control(DMSO) | 0 | 0 | 2.3 ± 1.2 |
2 | Indomethacin | 55 ± 10 | 15 ± 9 | * 10.5 ± 2.5 |
3 | DAHP pretreated indomethacin | 0 | 0 | * 11.5 ± 0.8 |
4 | Nabumetone | 0 | 0 | 2.7 ± 1.5 |