TY - JOUR AU - Thiagarajah, Jay R. AU - Griffiths, Nina M. AU - Pedley, Kevin C. AU - Naftalin, Richard J. PY - 2002 DA - 2002/02/12 TI - Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by Transforming Growth Factor β and Angiotensin II. JO - BMC Gastroenterology SP - 4 VL - 2 IS - 1 AB - Absorption of water and Na+ in descending colonic crypts is dependent on the barrier function of the surrounding myofibroblastic pericryptal sheath. Here the effects of high and low Na+ diets and exposure to whole body ionising radiation on the growth and activation of the descending colonic pericryptal myofibroblasts are evaluated. In addition the effect of a post-irradiation treatment with the angiotensin converting enzyme inhibitor Captopril was investigated. SN - 1471-230X UR - https://doi.org/10.1186/1471-230X-2-4 DO - 10.1186/1471-230X-2-4 ID - Thiagarajah2002 ER -