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Table 1 Clinicopathological characteristics NPM1 expression in gastric cancer samples

From: Deregulated expression of Nucleophosmin 1 in gastric cancer and its clinicopathological implications

 

NPM1 protein

NPM1mRNA

Variable

N

Ratio T/N (Mean ± SD)

Pvalue

N

RQ (Mean ± SD)

Pvalue

Gender

      

Male

8

0.81 ± 0.36

0.431

12

2.47 ± 3.86

0.657

Female

9

0.67 ± 0.39

 

10

1.76 ± 3.43

 

Onset (years)

      

< 45

5

0.73 ± 0.48

0.973

7

0.95 ± 0.89

0.298

≥ 45

12

0.74 ± 0.34

 

15

2.70 ± 4.25

 

Tumor location

      

Cardia

2

0.87 ± 0.04

0.601

2

0.17 ± 0.19

0.429

Non-cardia

15

0.72 ± 0.39

 

20

2.34 ± 3.73

 

Histological subtype

      

Diffuse-type

4

0.97 ± 0.25

0.159

6

0.33 ± 0.28

0.026*

Intestinal-type

13

0.66 ± 0.38

 

16

2.83 ± 4.04

 

Differentiation

      

Moderately differentiated

8

0.72 ± 0.38

0.492

10

2.84 ± 4.14

0.990

Poorly differentiated

5

0.57 ± 0.40

 

6

2.81 ± 4.26

 

Stage

      

Early

4

0.66 ± 0.31

0.675

4

1.02 ± 1.05

0.472

Advanced

13

0.76 ± 0.40

 

17

2.54 ±4 .01

 

Tumor invasion

      

T1/T2

7

0.78 ± 0.27

0.672

9

1.61 ± 1.63

0.502

T3/T4

10

0.70 ± 0.44

 

12

2.73 ± 4.67

 

Lymph node metastasis

      

Absent

6

0.78 ± 0.30

0.757

7

1.48 ± 1.82

0.509

Present

11

0.71 ± 0.42

 

14

2.63 ± 4.31

 

Distant metastasis

      

Unknown/absent

14

0.86 ± 0.26

< 0.001a

18

1.21 ± 1.29

0.220

Present

3

0.15 ± 0.20

 

3

8.49 ± 7.18

 
  1. T, tumor sample; N, matched non-neoplastic sample; SD, standard deviation; RQ, relative quantification – gastric tumor samples normalized by matched non-neoplastic sample. *Differentially expressed between groups, P <0.05, using t-test for independent samples.