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Table 4 Gene expression profiles for Fibrosis, inflammation and fatty acid trafficking

From: Fast food diet with CCl4 micro-dose induced hepatic-fibrosis –a novel animal model

Gene

Gene expression profile

Chow diet

0.5 ml/Kg B.wt CCl4

FFD

FFD + 0.5 ml/kg B.wt CCl4

Fibrosis

TGFβ1

1.02 ± 0.09

1.00 ± 0.05

1.22 ± 0.17

1.69 ± 0.14*

COL1A1

1.08 ± 0.17

1.56 ± 0.21

2.25 ± 0.32

13.05 ± 1.88***

TIMP1

1.00 ± 0.05

0.81 ± 0.04

1.74 ± 0.15

2.41 ± 0.42**

ACTA2

1.08 ± 0.08

1.00 ± 0.05

1.01 ± 0.12

0.87 ± 0.12

Inflammation

TNFα

1.05 ± 0.13

0.62 ± 0.04

3.59 ± 0.75**

1.30 ± 0.23*

Osetopontin

1.10 ± 0.34

0.86 ± 0.21

5.43 ± 1.14

9.79 ± 2.43**

Fatty acid trafficking

FABP4

1.05 ± 0.15

1.59 ± 0.28

5.63 ± 0.57

45.46 ± 8.64***

  1. Gene expression TGFB1, COlA1, TIMP1, Acta2, TNFa, FABP4 levels in liver; all data are expressed as mean ± SEM. The data measured by quantitative real-time RT-PCR was statistically analyzed for significant using one-way ANOVA followed by Dunnett’s multiple comparison post test, *p < 0.05, **p < 0.01 and ***p < 0.001.
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BMC Gastroenterology

ISSN: 1471-230X

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