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Table 4 Gene expression profiles for Fibrosis, inflammation and fatty acid trafficking

From: Fast food diet with CCl4 micro-dose induced hepatic-fibrosis –a novel animal model

Gene Gene expression profile
Chow diet 0.5 ml/Kg B.wt CCl4 FFD FFD + 0.5 ml/kg B.wt CCl4
Fibrosis
TGFβ1 1.02 ± 0.09 1.00 ± 0.05 1.22 ± 0.17 1.69 ± 0.14*
COL1A1 1.08 ± 0.17 1.56 ± 0.21 2.25 ± 0.32 13.05 ± 1.88***
TIMP1 1.00 ± 0.05 0.81 ± 0.04 1.74 ± 0.15 2.41 ± 0.42**
ACTA2 1.08 ± 0.08 1.00 ± 0.05 1.01 ± 0.12 0.87 ± 0.12
Inflammation
TNFα 1.05 ± 0.13 0.62 ± 0.04 3.59 ± 0.75** 1.30 ± 0.23*
Osetopontin 1.10 ± 0.34 0.86 ± 0.21 5.43 ± 1.14 9.79 ± 2.43**
Fatty acid trafficking
FABP4 1.05 ± 0.15 1.59 ± 0.28 5.63 ± 0.57 45.46 ± 8.64***
  1. Gene expression TGFB1, COlA1, TIMP1, Acta2, TNFa, FABP4 levels in liver; all data are expressed as mean ± SEM. The data measured by quantitative real-time RT-PCR was statistically analyzed for significant using one-way ANOVA followed by Dunnett’s multiple comparison post test, *p < 0.05, **p < 0.01 and ***p < 0.001.