Fast food diet with CCl4 micro-dose induced hepatic-fibrosis –a novel animal model

BMC Gastroenterology

Table 2 Effect on liver oxidative stress markers and liver triglyceride levels

Parameters	Chow diet control	0.5 ml/Kg B.wt CCl₄	FFD	FFD + 0.5 ml/kg B.wt CCl₄
Liver TG (mg/g tissue)	6.32 ± 0.79	8.73 ± 1.27	17.17 ± 0.96***	15.49 ± 1.51***
Liver GSH (μg/mg protein)	7.36 ± 0.62	6.81 ± 0.42	6.95 ± 0.45	2.58 ± 1.10**
Liver TBARS (μM/mg protein)	0.56 ± 0.06	0.60 ± 0.064	3.73 ± 0.67***	2.10 ± 0.29**
Relative Liver weight (g)	2.49 ± 0.04	2.86 ± 0.08	4.77 ± 0.15***	4.85 ± 0.16***

Data are expressed as mean ± SEM. Statistical significance was determined using one-way ANOVA followed by Dunnett’s multiple comparison post test, **p < 0.01 and ***p < 0.001.

ISSN: 1471-230X