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Table 4 Some biochemical variables in all subjects and in subjects with MetS according to NAFLD severity at ultrasound examination

From: NOX2-generated oxidative stress is associated with severity of ultrasound liver steatosis in patients with non-alcoholic fatty liver disease

  ALL SUBJECTS SUBJECTS WITH MetS
Variables N A F L D
  Absent (n = 51) Mild (n = 45) Moderate (n = 88) Severe (n = 80) P Absent (n = 10) Mild (n = 21) Moderate (n = 54) Severe (n = 63) P
Urinary 8-iso-PGF2α (pg/mg creatinine) 621,2 ± 125,9 674,3 ± 121,2 700,7 ± 108,4 751,3 ± 121,0 <,001 616,6 ± 213,2 700,2 ± 103,9 734,3 ± 34,5 761,9 ± 96,5 <,001
sNOX2-dp (pg/ml) 47,9 ± 9,9 52,9 ± 15,5 57,1 ± 13.3 60,0 ± 12,2 <.001 45,3 ± 14,2 56,0 ± 13,3 58,9 ± 12,6 60,4 ± 10.6 <,005
Adiponectin (ng/ml) 13,0 (8,0/15,0) 10,0 (5,5/12,0) 8,8 (6,0/13,5) 6,0 (4,9/9,0) <,001 12,5 (5,0/13,9) 9,4 (5,8/11,8) 7,5 (5,0/11,1) 6,0 (4,6/8,5) <,05
Cytokeratin 18 (mIU/ml) 136 (125/173) 169 (129/185) 176 (140/190) 180 (168/182) <,001 147 (128/182) 170 (132/188) 180 (162/190) 182 (175/195) <,05
ALT (IU/L) 18 (14/27) 21 (17/34) 26 (19/36) 34 (25/45) <,001 16 (12,/22) 26 (19/37) 25,5 (17/36,3) 32 (24/43) <,001
GGT (IU/L) 21 (14/30,5) 23 (16/40,7) 21 (16/35) 33,50 (24/61) <,001 14 (11/25) 25 (19/42) 22 (16/34) 34 (24/64) <,001
HOMA_IR 1,9 (1,3/2,3) 2,5 (1,7/3,8) 3,3 (2,2/5,4) 5,2 (3,1/7,3) <,001 2,9 (1,1/3,8) 2,9 (1,7/4,5) 3,9 (2,9/5,9) 5,6 (3,3/7,4) <,001
Metabolic syndrome (%)* 21,7 50,0 63,5 81,8 <,001 100 100 100 100 -
  1. *Defined according to ATPIII modified criteria (Ref. 30).