Table 4 Some biochemical variables in all subjects and in subjects with MetS according to NAFLD severity at ultrasound examination
ALL SUBJECTS | SUBJECTS WITH MetS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Variables | N A F L D | |||||||||
Absent (n = 51) | Mild (n = 45) | Moderate (n = 88) | Severe (n = 80) | P | Absent (n = 10) | Mild (n = 21) | Moderate (n = 54) | Severe (n = 63) | P | |
Urinary 8-iso-PGF2α (pg/mg creatinine) | 621,2 ± 125,9 | 674,3 ± 121,2 | 700,7 ± 108,4 | 751,3 ± 121,0 | <,001 | 616,6 ± 213,2 | 700,2 ± 103,9 | 734,3 ± 34,5 | 761,9 ± 96,5 | <,001 |
sNOX2-dp (pg/ml) | 47,9 ± 9,9 | 52,9 ± 15,5 | 57,1 ± 13.3 | 60,0 ± 12,2 | <.001 | 45,3 ± 14,2 | 56,0 ± 13,3 | 58,9 ± 12,6 | 60,4 ± 10.6 | <,005 |
Adiponectin (ng/ml) | 13,0 (8,0/15,0) | 10,0 (5,5/12,0) | 8,8 (6,0/13,5) | 6,0 (4,9/9,0) | <,001 | 12,5 (5,0/13,9) | 9,4 (5,8/11,8) | 7,5 (5,0/11,1) | 6,0 (4,6/8,5) | <,05 |
Cytokeratin 18 (mIU/ml) | 136 (125/173) | 169 (129/185) | 176 (140/190) | 180 (168/182) | <,001 | 147 (128/182) | 170 (132/188) | 180 (162/190) | 182 (175/195) | <,05 |
ALT (IU/L) | 18 (14/27) | 21 (17/34) | 26 (19/36) | 34 (25/45) | <,001 | 16 (12,/22) | 26 (19/37) | 25,5 (17/36,3) | 32 (24/43) | <,001 |
GGT (IU/L) | 21 (14/30,5) | 23 (16/40,7) | 21 (16/35) | 33,50 (24/61) | <,001 | 14 (11/25) | 25 (19/42) | 22 (16/34) | 34 (24/64) | <,001 |
HOMA_IR | 1,9 (1,3/2,3) | 2,5 (1,7/3,8) | 3,3 (2,2/5,4) | 5,2 (3,1/7,3) | <,001 | 2,9 (1,1/3,8) | 2,9 (1,7/4,5) | 3,9 (2,9/5,9) | 5,6 (3,3/7,4) | <,001 |
Metabolic syndrome (%)* | 21,7 | 50,0 | 63,5 | 81,8 | <,001 | 100 | 100 | 100 | 100 | - |