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Table 6 Prediction of clinical response in DIMS0150 treated patients (n = 22) using CD163, TSP-1 and IL-6

From: Biomarkers can predict potential clinical responders to DIMS0150 a toll-like receptor 9 agonist in ulcerative colitis patients

Patient Steroid response Enhancing Steroid response and enhancing
N01 1 0 0
N02 0 0 0
N03 0 0 0
N04 0 0 0
N05 0 0 0
N06 0 1 0
N07 0 0 0
N08 1 1 1
N09 0 0 0
N10 0 0 0
N11 0 0 0
N12 n.d. n.d. n.d.
R01 1 1 1
R02 1 0 1
R03 1 1 1
R04 1 1 1
R05 0 0 0
R06 1 1 1
R07 1 1 1
R08 1 1 1
R09 0 1 1
R10 1 1 1
  1. (N) Clinical Non-responder defined as DIMS0150 treated patients with no clinical response at week 1 and week 4.
  2. (R) Clinical Responder defined as DIMS0150 treated patients with a clinical response at week 1 and/or 4).
  3. (0) Negative in classification analysis (i.e., steroid sensitive and/or not enhanced).
  4. (1) Positive in classification analysis (i.e., steroid resistant and/or enhanced).
  5. (n.d.) No data (no blood was received from patient for biomarker analysis).